Recombinant Mouse Klotho (aa 35-982) Protein, CF

Name	Recombinant Mouse Klotho (aa 35-982) Protein, CF
Supplier	R&D Systems
Catalog	1819-KL
Category	Protein
Prices	$329.00
Sizes	50 µg
Species Reactivities	Mouse
Nature	Recombinant
Source	Chinese Hamster Ovary cell line, CHO-derived Ala35-Lys982 (Arg948Lys), with a C-terminal 6-His tag
Purity	>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Bioactivity	Measured in a cell proliferation assay using BaF3 mouse pro‑B cells transfected with human FGF RIIIc. The ED 50 for this effect is 0.04-0.4 µg/mL in the presence of 1 µg/mL of Recombinant Human FGF‑23 (Catalog # 2604-FG ) and 10 µg/mL of heparin.
Endotoxin	<0.01 EU per 1 μg of the protein by the LAL method.
SwissProt/Accession	AAI38260
Gene	Kl
Sequence	Ala35
Supplier Page	Shop

Product References

FGF23 promotes renal calcium reabsorption through the TRPV5 channel. - FGF23 promotes renal calcium reabsorption through the TRPV5 channel.

Andrukhova O, Smorodchenko A, Egerbacher M, Streicher C, Zeitz U, Goetz R, Shalhoub V, Mohammadi M, Pohl EE, Lanske B, Erben RG. EMBO J. 2014 Feb 3;33(3):229-46.

Klotho deficiency disrupts hematopoietic stem cell development and - Klotho deficiency disrupts hematopoietic stem cell development and

Vadakke Madathil S, Coe LM, Casu C, Sitara D. Am J Pathol. 2014 Mar;184(3):827-41.

Klotho suppresses cardiomyocyte apoptosis in mice with stress-induced cardiac - Klotho suppresses cardiomyocyte apoptosis in mice with stress-induced cardiac

Song S, Gao P, Xiao H, Xu Y, Si LY. PLoS One. 2013 Dec 10;8(12):e82968.

FGF23 suppresses chondrocyte proliferation in the presence of soluble - FGF23 suppresses chondrocyte proliferation in the presence of soluble

Kawai M, Kinoshita S, Kimoto A, Hasegawa Y, Miyagawa K, Yamazaki M, Ohata Y, Ozono K, Michigami T. J Biol Chem. 2013 Jan 25;288(4):2414-27.

Vitamin D receptor agonists increase klotho and osteopontin while decreasing - Vitamin D receptor agonists increase klotho and osteopontin while decreasing

Lau WL, Leaf EM, Hu MC, Takeno MM, Kuro-o M, Moe OW, Giachelli CM. Kidney Int. 2012 Dec;82(12):1261-70.