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ADAR2 Antibody (C-2): sc-398122

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Datasheets
  • ADAR2 Antibody (C-2) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
  • raised against amino acids 281-370 mapping within an internal region of ADAR2 of human origin
  • recommended for detection of all ADAR2 isoforms of human origin by WB, IP, IF and ELISA
  • m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ADAR2 Antibody (C-2) for WB applications. These reagents are now offered in bundles with ADAR2 Antibody (C-2) (see ordering information below).

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    SEE ALSO...

    ADAR2 Antibody (C-2) is a mouse monoclonal IgG2a antibody that detects ADAR2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ADAR2, also known as adenosine deaminase, RNA-specific (RED1), plays a crucial role in RNA editing by converting adenosine to inosine, which is essential for the proper functioning of various proteins, including the glutamate receptor subunit B. This editing process not only alters the amino acid sequence of proteins, potentially affecting their function, but also allows for the generation of new splice sites, thereby increasing the diversity of the proteome. ADAR2′s ability to modify its own pre-mRNA highlights a regulatory role in RNA processing, and translocation from the nucleolus to the nucleoplasm is associated with enhanced editing of substrates. Furthermore, alternative splicing of the ADAR2 gene results in multiple transcript variants, which may further influence RNA editing efficiency and specificity. Anti-ADAR2 antibody (C-2) serves as an invaluable tool for researchers studying the complexities of RNA editing and its implications in various biological processes and diseases.

    For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

    Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

    LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

    ADAR2 Antibody (C-2) References:

    1. RNA editing by ADAR2 is metabolically regulated in pancreatic islets and beta-cells.  |  Gan, Z., et al. 2006. J Biol Chem. 281: 33386-94. PMID: 16956888
    2. c-Jun amino-terminal kinase-1 mediates glucose-responsive upregulation of the RNA editing enzyme ADAR2 in pancreatic beta-cells.  |  Yang, L., et al. 2012. PLoS One. 7: e48611. PMID: 23139803
    3. Hyperactive hypothalamus, motivated and non-distractible chronic overeating in ADAR2 transgenic mice.  |  Akubuiro, A., et al. 2013. Genes Brain Behav. 12: 311-22. PMID: 23323881
    4. ADAR2 affects mRNA coding sequence edits with only modest effects on gene expression or splicing in vivo.  |  Dillman, AA., et al. 2016. RNA Biol. 13: 15-24. PMID: 26669816
    5. Accumulation of nuclear ADAR2 regulates adenosine-to-inosine RNA editing during neuronal development.  |  Behm, M., et al. 2017. J Cell Sci. 130: 745-753. PMID: 28082424
    6. A new strategy to increase RNA editing at the Q/R site of GluA2 AMPA receptor subunits by targeting alternative splicing patterns of ADAR2.  |  Chaytow, H., et al. 2021. J Neurosci Methods. 364: 109357. PMID: 34536489
    7. Atractylodes lancea volatile oils target ADAR2-miR-181a-5p signaling to mesenchymal stem cell chondrogenic differentiation.  |  Ye, S., et al. 2023. Anat Rec (Hoboken). 306: 3006-3020. PMID: 35446511
    8. Library Screening Reveals Sequence Motifs That Enable ADAR2 Editing at Recalcitrant Sites.  |  Jacobsen, CS., et al. 2023. ACS Chem Biol. 18: 2188-2199. PMID: 37040436
    9. Molecular Docking and Dynamics Simulation Studies Predict Potential Anti-ADAR2 Inhibitors: Implications for the Treatment of Cancer, Neurological, Immunological and Infectious Diseases.  |  Broni, E., et al. 2023. Int J Mol Sci. 24: PMID: 37047766
    10. The disruption of circadian rhythmicity of gene expression in the hippocampus and associated structures in Gria2R/R mice; a comparison with C57BL/6J and Adar2-/- mice strains.  |  Lebedeva, M., et al. 2024. Brain Res. 1826: 148739. PMID: 38157956

    Ordering Information

    Product NameCatalog #UNITPriceQtyFAVORITES

    ADAR2 Antibody (C-2)

    sc-398122
    200 µg/ml
    $316.00

    ADAR2 Antibody (C-2): m-IgG Fc BP-HRP Bundle

    sc-538370
    200 µg Ab; 10 µg BP
    $354.00

    ADAR2 Antibody (C-2): m-IgGκ BP-HRP Bundle

    sc-535972
    200 µg Ab; 40 µg BP
    $354.00

    ADAR2 Antibody (C-2): m-IgG2a BP-HRP Bundle

    sc-548281
    200 µg Ab; 10 µg BP
    $354.00

    For Western Blot, is it recommended to use denatured or non-denatured conditions with ADAR2 (C-2): sc-398122 monoclonal antibody?

    Asked by: Professor Griffin
    Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
    Answered by: Technical Support
    Date published: 2017-02-27
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    Rated 5 out of 5 by from this antibodiesThe antibodies of this product are mouse monoclonal IgG2a provided at 200 μg / ml, and according to its favorable properties.For amino acids 281-370 mapped in the internal region of human ADAR2
    Date published: 2017-02-09
    Rated 5 out of 5 by from Nice Western blot data of ADAR2 expression in nonNice Western blot data of ADAR2 expression in non-transfected and human ADAR2 transfected 293T whole cell lysates. -SCBT QC
    Date published: 2014-06-24
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    ADAR2 Antibody (C-2) is rated 5.0 out of 5 by 2.
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