ADAR2 Antibody (C-2): sc-398122

ADAR2 Antibody (C-2) is a mouse monoclonal IgG2a antibody that detects ADAR2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ADAR2, also known as adenosine deaminase, RNA-specific (RED1), plays a crucial role in RNA editing by converting adenosine to inosine, which is essential for the proper functioning of various proteins, including the glutamate receptor subunit B. This editing process not only alters the amino acid sequence of proteins, potentially affecting their function, but also allows for the generation of new splice sites, thereby increasing the diversity of the proteome. ADAR2′s ability to modify its own pre-mRNA highlights a regulatory role in RNA processing, and translocation from the nucleolus to the nucleoplasm is associated with enhanced editing of substrates. Furthermore, alternative splicing of the ADAR2 gene results in multiple transcript variants, which may further influence RNA editing efficiency and specificity. Anti-ADAR2 antibody (C-2) serves as an invaluable tool for researchers studying the complexities of RNA editing and its implications in various biological processes and diseases.

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ADAR2 Antibody (C-2) References:

1. RNA editing by ADAR2 is metabolically regulated in pancreatic islets and beta-cells.  |  Gan, Z., et al. 2006. J Biol Chem. 281: 33386-94. PMID: 16956888
2. c-Jun amino-terminal kinase-1 mediates glucose-responsive upregulation of the RNA editing enzyme ADAR2 in pancreatic beta-cells.  |  Yang, L., et al. 2012. PLoS One. 7: e48611. PMID: 23139803
3. Hyperactive hypothalamus, motivated and non-distractible chronic overeating in ADAR2 transgenic mice.  |  Akubuiro, A., et al. 2013. Genes Brain Behav. 12: 311-22. PMID: 23323881
4. ADAR2 affects mRNA coding sequence edits with only modest effects on gene expression or splicing in vivo.  |  Dillman, AA., et al. 2016. RNA Biol. 13: 15-24. PMID: 26669816
5. Accumulation of nuclear ADAR2 regulates adenosine-to-inosine RNA editing during neuronal development.  |  Behm, M., et al. 2017. J Cell Sci. 130: 745-753. PMID: 28082424
6. A new strategy to increase RNA editing at the Q/R site of GluA2 AMPA receptor subunits by targeting alternative splicing patterns of ADAR2.  |  Chaytow, H., et al. 2021. J Neurosci Methods. 364: 109357. PMID: 34536489
7. Atractylodes lancea volatile oils target ADAR2-miR-181a-5p signaling to mesenchymal stem cell chondrogenic differentiation.  |  Ye, S., et al. 2023. Anat Rec (Hoboken). 306: 3006-3020. PMID: 35446511
8. Library Screening Reveals Sequence Motifs That Enable ADAR2 Editing at Recalcitrant Sites.  |  Jacobsen, CS., et al. 2023. ACS Chem Biol. 18: 2188-2199. PMID: 37040436
9. Molecular Docking and Dynamics Simulation Studies Predict Potential Anti-ADAR2 Inhibitors: Implications for the Treatment of Cancer, Neurological, Immunological and Infectious Diseases.  |  Broni, E., et al. 2023. Int J Mol Sci. 24: PMID: 37047766
10. The disruption of circadian rhythmicity of gene expression in the hippocampus and associated structures in Gria2R/R mice; a comparison with C57BL/6J and Adar2-/- mice strains.  |  Lebedeva, M., et al. 2024. Brain Res. 1826: 148739. PMID: 38157956

The preferred ADAR2 antibody is ADAR2 Antibody (1.3.1): sc-73409.