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BMAL1 Antibody (B-1): sc-365645

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Datasheets
  • BMAL1 Antibody (B-1) is a mouse monoclonal IgG1 κ BMAL1 antibody, cited in 33 publications, provided at 200 µg/ml
  • raised against amino acids 441-610 mapping near the C-terminus of BMAL1 of human origin
  • BMAL1 Antibody (B-1) is recommended for detection of BMAL1 of mouse, rat and human origin by WB, IP, IF and ELISA
  • Anti-BMAL1 Antibody (B-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
  • also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
  • also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
  • TransCruz reagent for Gel Supershift and ChIP applications (sc-365645 X, 200 µg/0.1 ml)
  • Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of BMAL1 (B-1): sc-365645.
  • m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for BMAL1 Antibody (B-1) for WB applications. These reagents are now offered in bundles with BMAL1 Antibody (B-1) (see ordering information below).

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SEE ALSO...

BMAL1 Antibody (B-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects BMAL1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BMAL1 (B-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. BMAL1 protein, also known as brain and muscle Arnt-like protein 1, plays a crucial role in circadian rhythm regulation by forming a heterodimer with Clock protein, which then binds to promoter regions of target genes such as mPer1. This interaction maintains the body′s internal clock, influencing physiological processes including sleep-wake cycles, hormone release, and metabolism. Disruptions in BMAL1 function can lead to circadian rhythm disorders and have been linked to metabolic syndromes and other health issues. Additionally, BMAL1 belongs to a larger family of transcription factors including aromatic hydrocarbon receptor (AhR) and nuclear translocator proteins (Arnt 1 and Arnt 2), which are essential for ligand-dependent activation of genes involved in detoxification processes. anti-BMAL1 antibody (B-1) versatility in various applications makes this product an invaluable tool for researchers studying circadian biology and its implications in health and disease.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

BMAL1 Antibody (B-1) References:

  1. Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor.  |  Reyes, H., et al. 1992. Science. 256: 1193-5. PMID: 1317062
  2. Circadian rhythms in the absence of the clock gene Bmal1.  |  Ray, S., et al. 2020. Science. 367: 800-806. PMID: 32054765
  3. BMAL1-Downregulation Aggravates Porphyromonas Gingivalis-Induced Atherosclerosis by Encouraging Oxidative Stress.  |  Xie, M., et al. 2020. Circ Res. 126: e15-e29. PMID: 32078488
  4. An astrocyte BMAL1-BAG3 axis protects against alpha-synuclein and tau pathology.  |  Sheehan, PW., et al. 2023. Neuron. 111: 2383-2398.e7. PMID: 37315555
  5. Bmal1 downregulation leads to diabetic cardiomyopathy by promoting Bcl2/IP3R-mediated mitochondrial Ca2+ overload.  |  Zhang, N., et al. 2023. Redox Biol. 64: 102788. PMID: 37356134
  6. BMAL1 loss in oligodendroglia contributes to abnormal myelination and sleep.  |  Rojo, D., et al. 2023. Neuron. 111: 3604-3618.e11. PMID: 37657440
  7. Transcriptional activation domains of the Ah receptor and Ah receptor nuclear translocator.  |  Sogawa, K., et al. 1995. J Cancer Res Clin Oncol. 121: 612-20. PMID: 7559746
  8. cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt).  |  Hirose, K., et al. 1996. Mol Cell Biol. 16: 1706-13. PMID: 8657146
  9. Cloning and selective expression in brain and kidney of ARNT2 homologous to the Ah receptor nuclear translocator (ARNT).  |  Drutel, G., et al. 1996. Biochem Biophys Res Commun. 225: 333-9. PMID: 8753765
  10. cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS protein (BMAL1) and identification of alternatively spliced variants with alternative translation initiation site usage.  |  Ikeda, M. and Nomura, M. 1997. Biochem Biophys Res Commun. 233: 258-64. PMID: 9144434
  11. Ah receptor, a novel ligand-activated transcription factor.  |  Sogawa, K. and Fujii-Kuriyama, Y. 1997. J Biochem. 122: 1075-9. PMID: 9498548
  12. Circadian oscillation of BMAL1, a partner of a mammalian clock gene Clock, in rat suprachiasmatic nucleus.  |  Honma, S., et al. 1998. Biochem Biophys Res Commun. 250: 83-7. PMID: 9735336

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

BMAL1 Antibody (B-1)

sc-365645
200 µg/ml
$316.00

BMAL1 Antibody (B-1): m-IgG Fc BP-HRP Bundle

sc-529422
200 µg Ab; 10 µg BP
$354.00

BMAL1 Antibody (B-1): m-IgGκ BP-HRP Bundle

sc-522309
200 µg Ab, 40 µg BP
$354.00

BMAL1 Antibody (B-1) X

sc-365645 X
200 µg/0.1 ml
$316.00

BMAL1 Antibody (B-1) AC

sc-365645 AC
500 µg/ml, 25% agarose
$416.00

BMAL1 Antibody (B-1) HRP

sc-365645 HRP
200 µg/ml
$316.00

BMAL1 Antibody (B-1) FITC

sc-365645 FITC
200 µg/ml
$330.00

BMAL1 Antibody (B-1) PE

sc-365645 PE
200 µg/ml
$343.00

BMAL1 Antibody (B-1) Alexa Fluor® 488

sc-365645 AF488
200 µg/ml
$357.00

BMAL1 Antibody (B-1) Alexa Fluor® 546

sc-365645 AF546
200 µg/ml
$357.00

BMAL1 Antibody (B-1) Alexa Fluor® 594

sc-365645 AF594
200 µg/ml
$357.00

BMAL1 Antibody (B-1) Alexa Fluor® 647

sc-365645 AF647
200 µg/ml
$357.00

BMAL1 Antibody (B-1) Alexa Fluor® 680

sc-365645 AF680
200 µg/ml
$357.00

BMAL1 Antibody (B-1) Alexa Fluor® 790

sc-365645 AF790
200 µg/ml
$357.00

Hello! Our lab is interested in testing whether this antibody will react with Zebrafish Bmal1 (81% homology). Could we have a sample to test?

Asked by: Andy
Thank you for your interest in our sample program. To request a sample please contact our technical support team by emailing scbt@scbt.com
Answered by: BlakeJ
Date published: 2024-08-14

Bmal1的抗体中A-6和B-1的区别在于?

Asked by: l123456
Thank you for your question. A-6 and B-1 are different clone names for Bmal1 antibodies.
Answered by: Technical Service SH
Date published: 2023-12-05

可以申请试用装看一下使用效果吗

Asked by: wjw1998
感谢您的提问。如何获取免费试用装,请联系我们的技术支持部门。亚洲技术支持电话(+86) 021-60936350、邮箱asia@scbio.cn、或选择网页上Live Chat中的“中文支持”。 Thank you for your question. Please contact our Technical Service Department for more information on how to receive a free 10 ug sample of this monoclonal antibody. Our Asian Technical Service team is available at (+86) 021-60936350 or asia@scbio.cn or by live chat on our website.
Answered by: Jiajun Z
Date published: 2023-06-02

Have you done finer epitpope mapping within the BMAL1 aa441-610 immunogen?

Asked by: CJW1
No, the exact epitope recognized by this mouse monoclonal antibody has not yet been determined.
Answered by: Technical Support
Date published: 2019-01-06

What is the recommended secondary antibody for use with this mouse monoclonal BMAL1 Antibody (B-1): sc-365645?

Asked by: jerojero
We recommend trying one of our mouse binding proteins. A complete list of available binding proteins can be found at: https://www.scbt.com/scbt/browse/Antibodies-Secondary-Antibodies/_/N-1hoaxk4
Answered by: Technical Support 10
Date published: 2017-01-16
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Rated 4 out of 5 by from Bmal1 antibodyBmal1 mouse monoclonal antibody, 1/1000 dilution. Works well in western blotting.
Date published: 2023-06-30
Rated 5 out of 5 by from very goodthis antibody is very good! We strongly recommend using this antibody in other labs.
Date published: 2023-05-29
Rated 5 out of 5 by from Goodthis antibody is very good! we have great result for WB.
Date published: 2023-05-29
Rated 1 out of 5 by from Very faint signalI have tested this antibody by WB, using 40ug of mouse hippocampus, exposure for 10min, dilution 1:200 and the signal was still to faint to be reliable. The band had the expected size.
Date published: 2018-10-24
Rated 1 out of 5 by from can not detect specific band by WBit can not detect a specific band by WB in our lab.
Date published: 2017-09-18
Rated 5 out of 5 by from GOODI used this antibody to detect r WB (diluted 1:500), obtained clear bands
Date published: 2017-09-15
Rated 5 out of 5 by from Good specificityDilution detection 1:500. It shows the positive band
Date published: 2017-08-11
Rated 4 out of 5 by from WorksI used 1:200 dilution in milk on whole lysate of human lymphoblast and fibroblast. Good band detected.
Date published: 2017-07-17
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BMAL1 Antibody (B-1) is rated 4.1 out of 5 by 13.
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