Fos B Antibody (83B1138): sc-52926
- Fos B Antibody (83B1138) is a mouse monoclonal IgG1, cited in 1 publications, provided at 100 µg/ml
- raised against a synthetic Fos B peptide of human origin
- recommended for detection of Fos B of mouse, rat and human origin by WB, IP and IF
- See Fos B (F-7): sc-398595 for Fos B antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Fos B Antibody (83B1138). This work is in progress.
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FosB Antibody (83B1138) is a mouse monoclonal IgG1 antibody raised against a synthetic peptide from human FosB, a critical member of the AP-1 transcription factor family. Anti-FosB antibody (83B1138) recognizes an epitope within the FosB immunogen sequence and demonstrates broad species cross-reactivity, detecting FosB in mouse, rat, and human samples through Western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF) applications. FosB functions as a nuclear phosphoprotein that responds rapidly to various stimuli including stress and growth factors. Through formation of heterodimeric complexes with Jun proteins such as c-Jun and JunB, FosB binds to specific DNA sequences called TPA response elements (TREs), activating transcription of target genes. This sophisticated regulatory mechanism involves crucial post-translational modifications, particularly phosphorylation, which enhances FosB′s transcriptional activity and stability. FosB also engages in broader transcriptional networks through interactions with functional homologs Fra-1 and Fra-2, collectively orchestrating gene expression programs that control cell proliferation, differentiation, and stress responses. Also known as Fos-related antigen 2 (Fra-2), FosB serves as an essential coordinator of cellular responses to both external and internal signals. Through these diverse cellular functions, FosB (83B1138) antibody provides researchers with a valuable tool for investigating transcriptional regulation and signaling pathways.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fos B Antibody (83B1138) | sc-52926 | 100 µg/ml | $333.00 |