CRIP2 Antibody (H-10): sc-398980

CRIP2 Antibody (H-10) is a mouse monoclonal IgG1 antibody that detects Cysteine-rich protein 2 (CRIP2) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CRIP2 is a 208 amino acid protein characterized by two LIM zinc-binding domains that are linked to short glycine-rich repeats, along with a potential nuclear localization signal, which is crucial for cellular processes. CRIP2 plays a significant role in organizing multiprotein complexes, contributing to cytoskeletal remodeling in the cytoplasm and facilitating smooth muscle differentiation in the nucleus. This dual functionality underscores CRIP2′s importance in maintaining cellular structure and function, particularly in tissues such as the heart, where expression is most abundant. The human CRIP2 gene is located on chromosome 14q32.33, highlighting its genetic significance. With versatile applications and a critical role in cellular dynamics, anti-CRIP2 antibody (H-10) serves as an essential tool for researchers studying muscle differentiation and cytoskeletal organization.

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CRIP2 Antibody (H-10) References:

1. Polyclonal antibodies to LIM proteins CRP2 and CRIP2 reveal their subcellular localizations in olfactory precursor cells.  |  Gao, X., et al. 2009. Biochemistry (Mosc). 74: 336-41. PMID: 19364329
2. No NO, no pain? The role of nitric oxide and cGMP in spinal pain processing.  |  Schmidtko, A., et al. 2009. Trends Neurosci. 32: 339-46. PMID: 19414201
3. Cysteine-rich intestinal protein 2 (CRIP2) acts as a repressor of NF-kappaB-mediated proangiogenic cytokine transcription to suppress tumorigenesis and angiogenesis.  |  Cheung, AK., et al. 2011. Proc Natl Acad Sci U S A. 108: 8390-5. PMID: 21540330
4. Expression of Crip2, a LIM-domain-only protein, in the mouse cardiovascular system under physiological and pathological conditions.  |  Wei, TC., et al. 2011. Gene Expr Patterns. 11: 384-94. PMID: 21601656
5. The LIM domain protein, CRIP2, promotes apoptosis in esophageal squamous cell carcinoma.  |  Lo, PH., et al. 2012. Cancer Lett. 316: 39-45. PMID: 22154084
6. Transcriptomics of cortical gray matter thickness decline during normal aging.  |  Kochunov, P., et al. 2013. Neuroimage. 82: 273-83. PMID: 23707588
7. MiR-449a promotes breast cancer progression by targeting CRIP2.  |  Shi, W., et al. 2016. Oncotarget. 7: 18906-18. PMID: 26934316
8. HOXA9 inhibits HIF-1α-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development.  |  Zhou, L., et al. 2018. Nat Commun. 9: 1480. PMID: 29662084
9. APEX2-based Proximity Labeling of Atox1 Identifies CRIP2 as a Nuclear Copper-binding Protein that Regulates Autophagy Activation.  |  Chen, L., et al. 2021. Angew Chem Int Ed Engl. 60: 25346-25355. PMID: 34550632
10. Screening and verification of potential gene targets in esophageal carcinoma by bioinformatics analysis and immunohistochemistry.  |  Wen, P., et al. 2022. Ann Transl Med. 10: 70. PMID: 35282073

The preferred CRIP2 antibody is CRIP2 Antibody (C-2): sc-271659.