Fra1 Antibody (F-8): sc-271657
- Fra1 Antibody (F-8) is a mouse monoclonal IgG1 κ, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 3-34 at the N-terminus of Fra-1 of rat origin
- recommended for detection of Fra-1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- TransCruz reagent for ChIP application (sc-271657 X, 200 µg/0.1 ml)
- See Fra1 (D-3): sc-376148 for Fra1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Fra1 Antibody (F-8) for WB and IHC(P) applications. These reagents are now offered in bundles with Fra1 Antibody (F-8) (see ordering information below).
Fra-2 Antibody (G-5) is a mouse monoclonal IgG2a kappa light chain antibody raised against amino acids 180-282 of human Fra-2 (Fos-related antigen 2/FOSL2), a crucial nuclear transcription factor. Anti-Fra-2 antibody (G-5) recognizes an epitope within this region and demonstrates broad species cross-reactivity, detecting Fra-2 in mouse, rat, and human samples through Western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA) applications. Fra-2 maintains precise nuclear localization, where Fra-2 forms heterodimers with Jun family proteins, particularly c-Jun, through specialized leucine zipper and basic regions. These structural elements prove essential for both dimerization and DNA binding, enabling Fra-2-Jun complexes to recognize specific DNA sequences called TPA-responsive elements (TRE) within target gene promoters. Through this sophisticated mechanism, Fra-2 modulates transcriptional activity within the Activator Protein-1 (AP-1) complex, orchestrating the expression of genes controlling cell proliferation, differentiation, and apoptosis. Through these diverse cellular functions, Fra-2 (G-5) antibody provides researchers with a valuable tool for investigating transcriptional regulation and fundamental cellular processes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fra1 Antibody (F-8) | sc-271657 | 200 µg/ml | $316.00 | |||
Fra1 Antibody (F-8): m-IgG Fc BP-HRP Bundle | sc-537675 | 200 µg Ab; 10 µg BP | $354.00 | |||
Fra1 Antibody (F-8): m-IgGκ BP-HRP Bundle | sc-535016 | 200 µg Ab; 40 µg BP | $354.00 | |||
Fra1 Antibody (F-8): m-IgG1 BP-HRP Bundle | sc-545299 | 200 µg Ab; 20 µg BP | $354.00 | |||
Fra1 (F-8) Neutralizing Peptide | sc-271657 P | 100 µg/0.5 ml | $68.00 | |||
Fra1 Antibody (F-8) X | sc-271657 X | 200 µg/0.1 ml | $316.00 |