IκB-ε Antibody (21): sc-135945
- IκB-ε Antibody (21) is a mouse monoclonal IgG2a provided at 50 µg/0.5 ml
- raised against amino acids 200-211 of IκB-ε of human origin
- recommended for detection of IκB-ε of mouse, rat and human origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IκB-ε Antibody (21). This work is in progress.
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IκB-ε Antibody (21) is a mouse monoclonal IgG2a antibody that detects IκB-ε in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF) applications. IκB-ε is a crucial member of the IκB family of proteins, known for its role in regulating the NF-kB signaling pathway, which is vital for controlling immune responses, inflammation, and cell survival. IκB-ε is primarily located in the cytoplasm, where IκB-ε binds to the RelA and c-Rel subunits of NF-kB, preventing their translocation to the nucleus and thereby inhibiting the expression of target genes involved in inflammatory responses. IκB-ε′s cellular location is critical, as IκB-ε′s ability to sequester NF-kB in the cytoplasm is essential for maintaining cellular homeostasis and preventing excessive inflammatory signaling. Additionally, IκB-ε exists in several phosphorylated forms, which can influence IκB-ε′s stability and interaction with NF-kB, further underscoring the complexity of regulatory mechanisms. Anti-IκB-ε antibody (21) is an invaluable tool for researchers studying the intricacies of NF-kB signaling and its implications in various diseases, including cancer and autoimmune disorders.
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IκB-ε Antibody (21) References:
- Common pathway for the ubiquitination of IkappaBalpha, IkappaBbeta, and IkappaBepsilon mediated by the F-box protein FWD1. | Shirane, M., et al. 1999. J Biol Chem. 274: 28169-74. PMID: 10497169
- IkappaBalpha/IkappaBepsilon deficiency reveals that a critical NF-kappaB dosage is required for lymphocyte survival. | Goudeau, B., et al. 2003. Proc Natl Acad Sci U S A. 100: 15800-5. PMID: 14665694
- IkappaBepsilon provides negative feedback to control NF-kappaB oscillations, signaling dynamics, and inflammatory gene expression. | Kearns, JD., et al. 2006. J Cell Biol. 173: 659-64. PMID: 16735576
- Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon. | Stefansson, B. and Brautigan, DL. 2006. J Biol Chem. 281: 22624-34. PMID: 16769727
- Inhibitor of kappa B epsilon (IκBε) is a non-redundant regulator of c-Rel-dependent gene expression in murine T and B cells. | Clark, JM., et al. 2011. PLoS One. 6: e24504. PMID: 21915344
- IκBε is a key regulator of B cell expansion by providing negative feedback on cRel and RelA in a stimulus-specific manner. | Alves, BN., et al. 2014. J Immunol. 192: 3121-32. PMID: 24591377
- Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia. | Mansouri, L., et al. 2015. J Exp Med. 212: 833-43. PMID: 25987724
- Prediction of the presence of a seventh ankyrin repeat in IκBε from homology modeling combined with hydrogen-deuterium exchange mass spectrometry (HDX-MS). | Ramsey, KM., et al. 2018. Protein Sci. 27: 1624-1635. PMID: 30133030
- IκBε deficiency accelerates disease development in chronic lymphocytic leukemia. | Bordini, J., et al. 2024. Leukemia. 38: 1287-1298. PMID: 38575671
- I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity. | Whiteside, ST., et al. 1997. EMBO J. 16: 1413-26. PMID: 9135156
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IκB-ε Antibody (21) | sc-135945 | 50 µg/0.5 ml | $316.00 |