LZTR1 Antibody (E-12): sc-390166

LZTR1 Antibody (E-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects LZTR1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LZTR1 (E-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LZTR1 protein, known as leucine-zipper-like transcriptional regulator 1, is a crucial member of the BTB-kelch superfamily, characterized by two BTB (Broad-Complex, Tramtrack and Bric a brac) domains and six Kelch repeats. These structural features are significant as the BTB domain is involved in homodimerization and plays a vital role in transcriptional regulation by influencing chromatin structure and function. LZTR1 is predominantly expressed in fetal brain, heart, kidney, liver, and lung tissues, and is localized on the cytoplasmic surface of the Golgi network, where LZTR1 functions as a transcriptional regulator during embryogenesis. LZTR1 has been implicated in the etiology of velocardiofacial/DiGeorge syndrome, as LZTR1 gene resides within a chromosomal deletion region associated with this condition, highlighting LZTR1′s relevance in developmental biology and disease.

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LZTR1 Antibody (E-12) References:

1. Towards a proteome-scale map of the human protein-protein interaction network.  |  Rual, JF., et al. 2005. Nature. 437: 1173-8. PMID: 16189514
2. The BTB-kelch protein LZTR-1 is a novel Golgi protein that is degraded upon induction of apoptosis.  |  Nacak, TG., et al. 2006. J Biol Chem. 281: 5065-71. PMID: 16356934
3. The DiGeorge syndrome.  |  Dodson, WE., et al. 1969. Lancet. 1: 574-5. PMID: 4179863
4. Hereditary multicentric osteolysis with recessive transmission: a new syndrome.  |  Torg, JS., et al. 1969. J Pediatr. 75: 243-52. PMID: 5795345
5. The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila.  |  Zollman, S., et al. 1994. Proc Natl Acad Sci U S A. 91: 10717-21. PMID: 7938017
6. The POZ domain: a conserved protein-protein interaction motif.  |  Bardwell, VJ. and Treisman, R. 1994. Genes Dev. 8: 1664-77. PMID: 7958847
7. Crystal structure of the BTB domain from PLZF.  |  Ahmad, KF., et al. 1998. Proc Natl Acad Sci U S A. 95: 12123-8. PMID: 9770450

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LZTR1 Antibody (E-12) has 11 citations in a variety of scientific publications.

Primary antibodies like Anti-LZTR1 Antibody (E-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LZTR1 Antibody (E-12) Specifications

Alternate Product Name: LZTR1

Product Clone Name: E-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: LZTR1

Epitope Species: human

Product Reactivity/Detection: LZTR1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 11 citations in various scientific publications

Available Conjugates/Forms for LZTR1 Antibody (E-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin, X: TransCruz Reagent