MTGR1 Antibody (B-7): sc-390114
- MTGR1 Antibody (B-7) is a mouse monoclonal IgG1 κ MTGR1 antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 55-93 within an internal region of MTGR1 of human origin
- MTGR1 Antibody (B-7) is recommended for detection of MTGR1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine, bovine and porcine
- Anti-MTGR1 Antibody (B-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of MTGR1 (B-7): sc-390114.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MTGR1 Antibody (B-7) for WB applications. These reagents are now offered in bundles with MTGR1 Antibody (B-7) (see ordering information below).
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MTGR1 Antibody (B-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects MTGR1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MTGR1 (B-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MTGR1, also known as CBFA2T2, is a nuclear protein encoded by the human CBFA2T2 gene and plays a crucial role in regulating gene expression within the RUNX1/AML1-ETO/MTG8 chimeric protein complex, which is associated with acute myeloid leukemia due to chromosomal translocation t(8;21). This complex is vital for hematopoiesis, and MTGR1′s ability to repress RUNX1-dependent transcription is significant for maintaining normal cellular growth and differentiation. Additionally, MTGR1 is implicated as a tumor suppressor candidate in myeloid tumors, particularly those with deletions in the 20q10-13 region, and MTGR1′s homo-oligomerization and hetero-oligomerization with MTG8 highlight MTGR1′s importance in cellular signaling pathways. Ubiquitously expressed in both fetal and adult tissues, MTGR1 deletion has been observed in approximately 10% of polycythemia vera cases, underscoring MTGR1′s relevance in hematological malignancies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MTGR1 Antibody (B-7) References:
- Structure and expression pattern of a human MTG8/ETO family gene, MTGR1. | Morohoshi, F., et al. 2000. Gene. 241: 287-95. PMID: 10675041
- The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies. | Hoogeveen, AT., et al. 2002. Oncogene. 21: 6703-12. PMID: 12242670
- The expression and function of MTG/ETO family proteins during neurogenesis. | Koyano-Nakagawa, N. and Kintner, C. 2005. Dev Biol. 278: 22-34. PMID: 15649458
- Mtgr1 is a transcriptional corepressor that is required for maintenance of the secretory cell lineage in the small intestine. | Amann, JM., et al. 2005. Mol Cell Biol. 25: 9576-85. PMID: 16227606
- Deletion of Mtgr1 sensitizes the colonic epithelium to dextran sodium sulfate-induced colitis. | Martinez, JA., et al. 2006. Gastroenterology. 131: 579-88. PMID: 16890610
- The AML1-MTG8 leukemic fusion protein forms a complex with a novel member of the MTG8(ETO/CDR) family, MTGR1. | Kitabayashi, I., et al. 1998. Mol Cell Biol. 18: 846-58. PMID: 9447981
- EHT, a new member of the MTG8/ETO gene family, maps on 20q11 region and is deleted in acute myeloid leukemias. | Fracchiolla, NS., et al. 1998. Blood. 92: 3481-4. PMID: 9787195
- CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family. | Calabi, F. and Cilli, V. 1998. Genomics. 52: 332-41. PMID: 9790752
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MTGR1 Antibody (B-7) | sc-390114 | 200 µg/ml | $316.00 | |||
MTGR1 Antibody (B-7): m-IgG Fc BP-HRP Bundle | sc-530068 | 200 µg Ab; 10 µg BP | $354.00 | |||
MTGR1 Antibody (B-7): m-IgGκ BP-HRP Bundle | sc-523412 | 200 µg Ab, 40 µg BP | $354.00 | |||
MTGR1 Antibody (B-7): m-IgG1 BP-HRP Bundle | sc-543853 | 200 µg Ab; 20 µg BP | $354.00 | |||
MTGR1 Antibody (B-7) AC | sc-390114 AC | 500 µg/ml, 25% agarose | $416.00 | |||
MTGR1 Antibody (B-7) HRP | sc-390114 HRP | 200 µg/ml | $316.00 | |||
MTGR1 Antibody (B-7) FITC | sc-390114 FITC | 200 µg/ml | $330.00 | |||
MTGR1 Antibody (B-7) PE | sc-390114 PE | 200 µg/ml | $343.00 | |||
MTGR1 Antibody (B-7) Alexa Fluor® 488 | sc-390114 AF488 | 200 µg/ml | $357.00 | |||
MTGR1 Antibody (B-7) Alexa Fluor® 546 | sc-390114 AF546 | 200 µg/ml | $357.00 | |||
MTGR1 Antibody (B-7) Alexa Fluor® 594 | sc-390114 AF594 | 200 µg/ml | $357.00 | |||
MTGR1 Antibody (B-7) Alexa Fluor® 647 | sc-390114 AF647 | 200 µg/ml | $357.00 | |||
MTGR1 Antibody (B-7) Alexa Fluor® 680 | sc-390114 AF680 | 200 µg/ml | $357.00 | |||
MTGR1 Antibody (B-7) Alexa Fluor® 790 | sc-390114 AF790 | 200 µg/ml | $357.00 | |||
MTGR1 (B-7) Neutralizing Peptide | sc-390114 P | 100 µg/0.5 ml | $68.00 |