Optineurin Antibody (C-1): sc-271549
- Optineurin Antibody (C-1) is a mouse monoclonal IgG1 κ, cited in 6 publications, provided at 200 µg/ml
- raised against amino acids 321-540 mapping near the C-terminus of Optineurin of human origin
- Anti-Optineurin Antibody (C-1) is recommended for detection of Optineurin of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- Anti-Optineurin Antibody (C-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of Optineurin (C-1): sc-271549.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Optineurin Antibody (C-1) for WB and IHC(P) applications. These reagents are now offered in bundles with Optineurin Antibody (C-1) (see ordering information below).
QUICK LINKS
SEE ALSO...
Optineurin Antibody (C-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects Optineurin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Optineurin antibody (C-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Optineurin, also known as FIP2, plays a crucial role in cellular processes such as cell morphogenesis, membrane trafficking, and transcriptional activation by interacting with key proteins like Rab8 and Huntingtin. Localization to the Golgi apparatus is significant, as this organelle is essential for protein processing and sorting, which are vital for maintaining cellular homeostasis and function. Mutations in Optineurin have been linked to normal-tension glaucoma and adult-onset primary open-angle glaucoma, highlighting significance in ocular health. Optineurin consists of 617 amino acids and features structural motifs such as leucine zippers and leucine-rich regions, along with a potential Cys2-His-Cys zinc finger domain, which may be involved in protein-protein interactions and regulatory functions. Expression studies have shown that Optineurin is present in various human tissues, including trabecular meshwork, retina, brain, and liver, indicating diverse roles in different biological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Optineurin Antibody (C-1) | sc-271549 | 200 µg/ml | $316.00 | |||
Optineurin Antibody (C-1): m-IgG Fc BP-HRP Bundle | sc-527255 | 200 µg Ab; 10 µg BP | $354.00 | |||
Optineurin Antibody (C-1): m-IgG1 BP-HRP Bundle | sc-532628 | 200 µg Ab; 20 µg BP | $354.00 | |||
Optineurin Antibody (C-1) AC | sc-271549 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Optineurin Antibody (C-1) HRP | sc-271549 HRP | 200 µg/ml | $316.00 | |||
Optineurin Antibody (C-1) FITC | sc-271549 FITC | 200 µg/ml | $330.00 | |||
Optineurin Antibody (C-1) PE | sc-271549 PE | 200 µg/ml | $343.00 | |||
Optineurin Antibody (C-1) Alexa Fluor® 488 | sc-271549 AF488 | 200 µg/ml | $357.00 | |||
Optineurin Antibody (C-1) Alexa Fluor® 546 | sc-271549 AF546 | 200 µg/ml | $357.00 | |||
Optineurin Antibody (C-1) Alexa Fluor® 594 | sc-271549 AF594 | 200 µg/ml | $357.00 | |||
Optineurin Antibody (C-1) Alexa Fluor® 647 | sc-271549 AF647 | 200 µg/ml | $357.00 | |||
Optineurin Antibody (C-1) Alexa Fluor® 680 | sc-271549 AF680 | 200 µg/ml | $357.00 | |||
Optineurin Antibody (C-1) Alexa Fluor® 790 | sc-271549 AF790 | 200 µg/ml | $357.00 |