Smad2 Antibody (A-11): sc-393312

Smad2 Antibody (A-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects Smad2 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-Smad2 antibody (A-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Smad2 plays a crucial role in the transforming growth factor-beta (TGF-β) signaling pathway, which is essential for regulating cellular processes such as proliferation, differentiation, and apoptosis. Located primarily in the cytoplasm and nucleus, Smad2 transduces signals from TGF-β and Activin receptors, facilitating the transcription of target genes that govern these vital cellular functions. Proper localization of Smad2 ensures effective activation of the signaling cascade in response to extracellular cues, thereby influencing developmental processes and tissue homeostasis. Dysregulation of Smad2 activity has been implicated in various diseases, including cancer and fibrosis, highlighting Smad2′s importance as a therapeutic target.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Smad2 Antibody (A-11) has 15 citations in a variety of scientific publications.

Primary antibodies like Anti-Smad2 Antibody (A-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Smad2 Antibody (A-11) Specifications

Alternate Product Name: Smad2

Product Clone Name: A-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 80-120

Epitope Target: Smad2

Epitope Species: human

Product Reactivity/Detection: Smad2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: equine, canine, bovine, porcine and avian

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 15 citations in various scientific publications

Available Conjugates/Forms for Smad2 Antibody (A-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin, X: TransCruz Reagent

The preferred Smad2/3 antibody is Smad2/3 Antibody (C-8): sc-133098.