splicing factor 1 Antibody (E-9): sc-365269

Splicing factor 1 Antibody (E-9) is a mouse monoclonal IgG2a antibody that detects splicing factor 1 (SF1) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SF1 (E-9) antibody recognizes the seven-nucleotide branch point sequence at 3′ splice sites, which is essential for the assembly of early spliceosomal complexes. SF1 monoclonal antibody (E-9) influences the splicing of pre-mRNA, affecting the production of mature mRNA and ultimately the synthesis of proteins vital for various cellular processes. Anti-SF1 antibody (E-9) targets a protein involved in the transcriptional repression of pro-inflammatory genes, which can impact smooth muscle cell proliferation and contribute to the pathogenesis of hyperproliferative inflammatory diseases when its expression is downregulated by cytokines. SF1 (E-9) monoclonal antibody recognizes a protein structure that includes a nuclear transport domain, a metal binding motif, and regions rich in glutamine and proline, which are important for functional versatility and interaction with other proteins. The human SF1 gene is located on chromosome 11, near the MEN1 gene, which is associated with multiple endocrine neoplasia-type 1, highlighting potential implications in both normal physiology and disease states.

The preferred splicing factor 1 antibody is splicing factor 1 Antibody (H-9): sc-398881.