TFIIIB90-1 Antibody (BRF1G2A8): sc-81405
- TFIIIB90-1 Antibody (BRF1G2A8) is a mouse monoclonal IgG1 TFIIIB90-1 antibody, cited in 9 publications, provided at 100 µg/ml
- raised against a recombinant protein corresponding to a region near the C-terminus of TFIIIB90-1 of human origin
- recommended for detection of TFIIIB90-1 of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TFIIIB90-1 Antibody (BRF1G2A8). This work is in progress.
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TFIIIB90-1 Antibody (BRF1G2A8) is a mouse monoclonal IgG1 antibody that detects TFIIIB90-1 of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-TFIIIB90-1 antibody (BRF1G2A8) is available as a non-conjugated format. TFIIIB90-1 plays a crucial role in gene transcription by RNA polymerase III, which synthesizes essential RNA molecules such as tRNA and 5S rRNA. This function is particularly important since proper regulation of RNA polymerase III activity is vital for cellular growth and proliferation, especially in rapidly dividing cells. The TFIIIB complex, including TFIIIB90-1, is essential for recruiting RNA polymerase III to promoters, and dysregulation can lead to increased transcriptional activity often observed in cancerous cells. In many malignancies, inactivation of tumor suppressors like retinoblastoma (RB) and p53 disrupts normal regulatory mechanisms, allowing overexpression of TFIIIB and associated factors, thereby contributing to tumorigenesis. TFIIIB90-1 (BRF1G2A8) antibody serves as an invaluable tool for researchers studying molecular mechanisms of transcription regulation and implications in cancer biology.
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TFIIIB90-1 Antibody (BRF1G2A8) References:
- The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity. | Hsieh, YJ., et al. 1999. Mol Cell Biol. 19: 7697-704. PMID: 10523658
- Interactions between the tetratricopeptide repeat-containing transcription factor TFIIIC131 and its ligand, TFIIIB70. Evidence for a conformational change in the complex. | Moir, RD., et al. 2000. J Biol Chem. 275: 26591-8. PMID: 10859316
- Alternatively spliced hBRF variants function at different RNA polymerase III promoters. | McCulloch, V., et al. 2000. EMBO J. 19: 4134-43. PMID: 10921893
- Different human TFIIIB activities direct RNA polymerase III transcription from TATA-containing and TATA-less promoters. | Schramm, L., et al. 2000. Genes Dev. 14: 2650-63. PMID: 11040218
- RNA polymerase III transcription factor TFIIIC2 is overexpressed in ovarian tumors. | Winter, AG., et al. 2000. Proc Natl Acad Sci U S A. 97: 12619-24. PMID: 11058163
- Retinoblastoma protein disrupts interactions required for RNA polymerase III transcription. | Sutcliffe, JE., et al. 2000. Mol Cell Biol. 20: 9192-202. PMID: 11094071
- RNA polymerase III transcription: its control by tumor suppressors and its deregulation by transforming agents. | Brown, TR., et al. 2000. Gene Expr. 9: 15-28. PMID: 11097422
- Activation of mouse genes in transformed cells. | Scott, MR., et al. 1983. Cell. 34: 557-67. PMID: 6311432
- Expression of neural BC1 RNA: induction in murine tumours. | Chen, W., et al. 1997. Eur J Cancer. 33: 288-92. PMID: 9135502
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TFIIIB90-1 Antibody (BRF1G2A8) | sc-81405 | 100 µg/ml | $333.00 |