casein kinase IIα Antibody (1AD9): sc-12738

Casein kinase IIα Antibody (1AD9) is a mouse monoclonal IgG1 kappa light chain antibody designed to detect casein kinase IIα protein, also known as CK2α or CSNK2A1. Casein kinase IIα monoclonal antibody (1AD9) is raised against purified human casein kinase IIα and is effective in various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin embedded sections (IHCP) across multiple species such as mouse, rat, human, and bovine. Casein kinase IIα is a crucial serine/threonine protein kinase involved in regulating numerous cellular processes, including cell cycle progression, DNA replication and repair, apoptosis, and transcriptional regulation. Casein kinase IIα is vital for maintaining cellular homeostasis and is often dysregulated in cancer, making CK2α an important target for research into tumorigenesis and other proliferative diseases. CK2α subunit typically forms a tetrameric complex with regulatory β subunits, enhancing catalytic function through autophosphorylation. Through phosphorylating over 100 substrates, including nuclear oncoproteins and transcription factors, CK2α plays a pivotal role in cellular signaling pathways and gene expression. Casein kinase IIα (1AD9) antibody is available in both non-conjugated and various conjugated forms, such as agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® variants, providing versatility for diverse experimental needs.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

casein kinase IIα Antibody (1AD9) References:

1. Casein kinase I and II--multipotential serine protein kinases: structure, function, and regulation.  |  Tuazon, PT. and Traugh, JA. 1991. Adv Second Messenger Phosphoprotein Res. 23: 123-64. PMID: 1997039
2. Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II.  |  Lozeman, FJ., et al. 1990. Biochemistry. 29: 8436-47. PMID: 2174700
3. Casein kinase I gamma subfamily. Molecular cloning, expression, and characterization of three mammalian isoforms and complementation of defects in the Saccharomyces cerevisiae YCK genes.  |  Zhai, L., et al. 1995. J Biol Chem. 270: 12717-24. PMID: 7759525
4. Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family.  |  Fish, KJ., et al. 1995. J Biol Chem. 270: 14875-83. PMID: 7797465
5. Protein kinases. 4. Protein kinase CK2: an enzyme with multiple substrates and a puzzling regulation.  |  Allende, JE. and Allende, CC. 1995. FASEB J. 9: 313-23. PMID: 7896000
6. Casein kinase II in signal transduction and cell cycle regulation.  |  Litchfield, DW. and Lüscher, B. 1993. Mol Cell Biochem. 127-128: 187-99. PMID: 7935350
7. Molecular cloning, expression, and characterization of a 49-kilodalton casein kinase I isoform from rat testis.  |  Graves, PR., et al. 1993. J Biol Chem. 268: 6394-401. PMID: 8454611

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-casein kinase IIα Antibody (1AD9) has 48 citations in a variety of scientific publications.

Primary antibodies like Anti-casein kinase IIα Antibody (1AD9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

casein kinase IIα Antibody (1AD9) Specifications

Alternate Product Name: casein kinase 2 alpha

Product Clone Name: 1AD9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: casein kinase IIα

Epitope Species: human

Product Reactivity/Detection: casein kinase IIα

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: bovine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 48 citations in various scientific publications

Available Conjugates/Forms for casein kinase IIα Antibody (1AD9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin