Dia 2 Antibody (C-7): sc-55540
- Dia 2 Antibody (C-7) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against mino acids 23-110 mapping near the N-terminus of Dia 2 of human origin
- recommended for detection of Dia 2 (also designated mDia3 of mouse origin) of mouse, rat and human origin of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Dia 2 Antibody (C-7) for WB and IHC(P) applications. These reagents are now offered in bundles with Dia 2 Antibody (C-7) (see ordering information below).
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Dia 2 Antibody (C-7) is a mouse monoclonal IgG1 antibody that detects Dia 2 in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Dia 2, also known as DIAPH2 or mDia3, is a critical member of the formin family of proteins, which play a vital role in regulating actin dynamics within cells. Dia 2 (C-7) antibody targets a protein primarily located in the cytoplasm that′s essential for forming and elongating actin filaments, crucial for cell motility, division, and shape maintenance. Dia 2 monoclonal antibody (C-7) recognizes a protein particularly important in reproductive tissues, as Dia 2 has been implicated in oogenesis and is expressed in testis and ovary. Mutations or defects in the gene encoding Dia 2 have been associated with premature ovarian failure type 2A, a condition leading to reduced ovarian function and fertility issues. Dia 2 exists in three alternatively spliced isoforms, which may have distinct regulatory roles in cellular processes. Through interactions with Rho GTPases and other signaling molecules, anti-Dia 2 antibody (C-7) helps researchers study a key player in cellular signaling pathways, making this tool invaluable for investigating actin dynamics and related disorders.
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Dia 2 Antibody (C-7) References:
- The F-box protein Dia2 regulates DNA replication. | Koepp, DM., et al. 2006. Mol Biol Cell. 17: 1540-8. PMID: 16421250
- Yra1 is required for S phase entry and affects Dia2 binding to replication origins. | Swaminathan, S., et al. 2007. Mol Cell Biol. 27: 4674-84. PMID: 17452447
- Involvements of a novel protein, DIA2, in cAMP signaling and spore differentiation during Dictyostelium development. | Hirata, K., et al. 2008. Differentiation. 76: 310-22. PMID: 17825085
- Activation of the S-phase checkpoint inhibits degradation of the F-box protein Dia2. | Kile, AC. and Koepp, DM. 2010. Mol Cell Biol. 30: 160-71. PMID: 19858292
- The amino-terminal TPR domain of Dia2 tethers SCF(Dia2) to the replisome progression complex. | Morohashi, H., et al. 2009. Curr Biol. 19: 1943-9. PMID: 19913425
- Dia2 controls transcription by mediating assembly of the RSC complex. | Andress, EJ., et al. 2011. PLoS One. 6: e21172. PMID: 21701592
- Hect E3 ubiquitin ligase Tom1 controls Dia2 degradation during the cell cycle. | Kim, DH. and Koepp, DM. 2012. Mol Biol Cell. 23: 4203-11. PMID: 22933573
- DIA-2, a polyherbal formulation ameliorates hyperglycemia and protein-oxidation without increasing the body weight in type II diabetic rats. | Kesavanarayanan, KS., et al. 2013. Eur Rev Med Pharmacol Sci. 17: 356-69. PMID: 23426539
- Herbal formulation, DIA-2 and Rosiglitazone ameliorates hyperglycemia and hepatic steatosis in type 2 diabetic rats. | Kesavanarayanan, KS., et al. 2015. Eur Rev Med Pharmacol Sci. 19: 3107-17. PMID: 26367735
- Underexpression of a novel gene, dia2, impairs the transition of Dictyostelium cells from growth to differentiation. | Chae, SC., et al. 1998. Biochem Biophys Res Commun. 252: 278-83. PMID: 9813183
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dia 2 Antibody (C-7) | sc-55540 | 200 µg/ml | $316.00 | |||
Dia 2 Antibody (C-7): m-IgG Fc BP-HRP Bundle | sc-537067 | 200 µg Ab; 10 µg BP | $354.00 | |||
Dia 2 Antibody (C-7): m-IgGκ BP-HRP Bundle | sc-534253 | 200 µg Ab; 40 µg BP | $354.00 | |||
Dia 2 Antibody (C-7): m-IgG1 BP-HRP Bundle | sc-544984 | 200 µg Ab; 20 µg BP | $354.00 |