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IKKα Antibody (B-8) is a mouse monoclonal IgG2b kappa light chain antibody that detects IKKα protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). IKKα Antibody (B-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. IKKα plays a pivotal role in the regulation of the NFkB signaling pathway, which is crucial for controlling immune responses, inflammation, and cell survival. Located primarily in the cytoplasm, IKKα is part of a multi-subunit complex that includes IKKβ and IKKγ (NEMO), and is essential for the phosphorylation of the inhibitory protein IkB. This phosphorylation event is critical because IKKα leads to the degradation of IkB, allowing the transcription factor NFkB to translocate to the nucleus and activate target genes involved in inflammatory responses. IKKα interaction with IkB-α, particularly phosphorylation at serine residues 32 and 36, is a key regulatory step in the NFkB activation process, which is stimulated by upstream signals such as tumor necrosis factor (TNF) and interleukin-1 (IL-1) through the NFkB inducing kinase (NIK). Understanding IKKα function and regulation is vital for elucidating the mechanisms underlying various inflammatory diseases and developing targeted therapies.
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Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IKK alpha Antibody (B-8) | sc-7606 | 200 µg/ml | $316.00 | |||
IKK alpha Antibody (B-8): m-IgG Fc BP-HRP Bundle | sc-528184 | 200 µg Ab; 10 µg BP | $354.00 | |||
IKK alpha Antibody (B-8): m-IgGκ BP-HRP Bundle | sc-520505 | 200 µg Ab, 40 µg BP | $354.00 | |||
IKK alpha Antibody (B-8): m-IgG2b BP-HRP Bundle | sc-550005 | 200 µg Ab; 10 µg BP | $354.00 | |||
IKK alpha Antibody (B-8) X | sc-7606 X | 200 µg/0.1 ml | $316.00 | |||
IKK alpha Antibody (B-8) AC | sc-7606 AC | 500 µg/ml, 25% agarose | $416.00 | |||
IKK alpha Antibody (B-8) HRP | sc-7606 HRP | 200 µg/ml | $316.00 | |||
IKK alpha Antibody (B-8) FITC | sc-7606 FITC | 200 µg/ml | $330.00 | |||
IKK alpha Antibody (B-8) PE | sc-7606 PE | 200 µg/ml | $343.00 | |||
IKK alpha Antibody (B-8) Alexa Fluor® 488 | sc-7606 AF488 | 200 µg/ml | $357.00 | |||
IKK alpha Antibody (B-8) Alexa Fluor® 546 | sc-7606 AF546 | 200 µg/ml | $357.00 | |||
IKK alpha Antibody (B-8) Alexa Fluor® 594 | sc-7606 AF594 | 200 µg/ml | $357.00 | |||
IKK alpha Antibody (B-8) Alexa Fluor® 647 | sc-7606 AF647 | 200 µg/ml | $357.00 | |||
IKK alpha Antibody (B-8) Alexa Fluor® 680 | sc-7606 AF680 | 200 µg/ml | $357.00 | |||
IKK alpha Antibody (B-8) Alexa Fluor® 790 | sc-7606 AF790 | 200 µg/ml | $357.00 | |||
IKK alpha Antibody (B-8) TRITC | sc-7606 TRITC | 200 µg/ml | $320.00 | |||
IKK alpha Antibody (B-8) Alexa Fluor® 405 | sc-7606 AF405 | 200 µg/ml | $357.00 |