Mnk2 Antibody (B-6): sc-271559

Mnk2 Antibody (B-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects Mnk2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Mnk2 antibody (B-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Mnk2 plays a crucial role in cellular signaling pathways, particularly in regulating protein synthesis in response to stress signals. Mnk2 is primarily located in the cytoplasm, where Mnk2 interacts with eukaryotic translation initiation factor 4E (eIF4E), a key player in translation initiation. This interaction enables eIF4E phosphorylation, which enhances affinity for the mRNA cap structure, promoting translation of specific mRNAs critical for cell survival and proliferation under stress conditions. Mnk2 drives various cellular processes, including cell growth, differentiation, and apoptosis, making Mnk2 an important target for research in cancer and other diseases. Mnk2 exists in multiple isoforms, such as Mnk2a and Mnk2b, due to alternative splicing, which may have distinct regulatory roles in different cellular contexts.

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Mnk2 Antibody (B-6) References:

1. MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase.  |  Stokoe, D., et al. 1992. EMBO J. 11: 3985-94. PMID: 1327754
2. Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II.  |  Sturgill, TW., et al. 1988. Nature. 334: 715-8. PMID: 2842685
3. RSK3 encodes a novel pp90rsk isoform with a unique N-terminal sequence: growth factor-stimulated kinase function and nuclear translocation.  |  Zhao, Y., et al. 1995. Mol Cell Biol. 15: 4353-63. PMID: 7623830
4. The mitogen-activated protein kinase signal transduction pathway.  |  Davis, RJ. 1993. J Biol Chem. 268: 14553-6. PMID: 8325833
5. 3pK, a new mitogen-activated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region.  |  Sithanandam, G., et al. 1996. Mol Cell Biol. 16: 868-76. PMID: 8622688
6. Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase.  |  McLaughlin, MM., et al. 1996. J Biol Chem. 271: 8488-92. PMID: 8626550
7. Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2.  |  Waskiewicz, AJ., et al. 1997. EMBO J. 16: 1909-20. PMID: 9155017
8. MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates.  |  Fukunaga, R. and Hunter, T. 1997. EMBO J. 16: 1921-33. PMID: 9155018

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Mnk2 Antibody (B-6) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-Mnk2 Antibody (B-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Mnk2 Antibody (B-6) Specifications

Alternate Product Name: Mnk2

Product Clone Name: B-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 3-34

Epitope Target: Mnk2

Epitope Species: mouse

Product Reactivity/Detection: Mnk2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for Mnk2 Antibody (B-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin