p38 gamma MAPK12 Antibody (E-11): sc-365487

p38 gamma MAPK12 Antibody (E-11) is a mouse monoclonal IgG3 antibody that detects p38 gamma MAPK12 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). p38 gamma MAPK12, a member of the mitogen-activated protein kinase family, plays a crucial role in various cellular processes, including stress responses, inflammation, and cell differentiation. p38 gamma MAPK12 is primarily located in the cytoplasm, where activation occurs in response to environmental stressors and cytokines, leading to phosphorylation of downstream targets that regulate gene expression and cell fate decisions. Proper localization of p38 gamma MAPK12 is essential for function, allowing rapid signaling in response to stimuli, ensuring cells can adapt to changing conditions. p38 gamma MAPK12 interacts with other signaling proteins, such as MKK3 and MKK6, which are upstream activators that facilitate activation. Phosphorylation of p38 gamma MAPK12 on specific threonine and tyrosine residues is critical for enzymatic activity, underscoring the importance of post-translational modifications in regulating function and signaling pathways. With versatile applications and significant role in cellular signaling, anti-p38 gamma MAPK12 antibody (E-11) is an invaluable tool for researchers studying MAPK signaling and its implications in health and disease.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

p38 gamma MAPK12 Antibody (E-11) References:

1. p38gamma mitogen-activated protein kinase suppresses chondrocyte production of MMP-13 in response to catabolic stimulation.  |  Long, DL. and Loeser, RF. 2010. Osteoarthritis Cartilage. 18: 1203-10. PMID: 20633667
2. p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation.  |  González-Terán, B., et al. 2016. Nat Commun. 7: 10477. PMID: 26795633
3. p38γ and p38δ reprogram liver metabolism by modulating neutrophil infiltration.  |  González-Terán, B., et al. 2016. EMBO J. 35: 536-52. PMID: 26843485
4. Phenotype-Based Screens with Conformation-Specific Inhibitors Reveal p38 Gamma and Delta as Targets for HCC Polypharmacology.  |  Yu, JX., et al. 2019. Mol Cancer Ther. 18: 1506-1519. PMID: 31213506
5. p38gamma overexpression promotes renal cell carcinoma cell growth, proliferation and migration.  |  Chen, XF., et al. 2019. Biochem Biophys Res Commun. 516: 466-473. PMID: 31229268
6. p38γ MAPK Is Essential for Aerobic Glycolysis and Pancreatic Tumorigenesis.  |  Wang, F., et al. 2020. Cancer Res. 80: 3251-3264. PMID: 32580961
7. Combination of QSAR Modeling and Hybrid-Based Consensus Scoring to Identify Dual-Targeting Inhibitors of PLK1 and p38γ.  |  Cheng, Z., et al. 2023. J Chem Inf Model. 63: 6912-6924. PMID: 37883148
8. Targeting p38γ synergistically enhances sorafenib-induced cytotoxicity in hepatocellular carcinoma.  |  Huang, C., et al. 2025. Cell Biol Toxicol. 41: 35. PMID: 39871031
9. The primary structure of p38 gamma: a new member of p38 group of MAP kinases.  |  Li, Z., et al. 1996. Biochem Biophys Res Commun. 228: 334-40. PMID: 8920915

The preferred p38 gamma MAPK12 antibody is p38 gamma MAPK12 Antibody (E-4): sc-398546.