PKD2 Antibody (431.2): sc-100415
- PKD2 Antibody (431.2) is a mouse monoclonal IgG2b κ, cited in 5 publications, provided at 50 µg/0.5 ml
- raised against recombinant PKD2 of human origin
- recommended for detection of PKD2 of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PKD2 Antibody (431.2). This work is in progress.
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PKD2 Antibody (431.2) is a mouse monoclonal IgG2b antibody that detects PKD2 in human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). PKD2, also known as protein kinase D2 or PRKD2, plays a crucial role in cellular signaling pathways, particularly in the regulation of proliferation, apoptosis, and migration. PKD2 is primarily located in the cytoplasm but can translocate to the nucleus upon activation, which is essential for function in gene expression regulation. PKD2′s ability to shuttle between cellular compartments allows influence on various biological processes, including transcriptional activation of target genes such as Nur77, while also modulating histone deacetylase 7 (HDAC7) activity. Phosphorylation of PKD2 by casein kinase I isoforms upon stimulation of the CCK-BR receptor highlights PKD2′s role in mediating signaling cascades that lead to significant cellular responses. With unique structural features, including a PH domain and phorbol-ester/DAG-type zinc fingers, PKD2 is a vital component in the intricate network of cellular signaling, making anti-PKD2 antibody (431.2) an invaluable tool for researchers studying these pathways in human tissues.
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PKD2 Antibody (431.2) References:
- Mutations of the human polycystic kidney disease 2 (PKD2) gene. | Deltas, CC. 2001. Hum Mutat. 18: 13-24. PMID: 11438989
- Structure of the human PKD1-PKD2 complex. | Su, Q., et al. 2018. Science. 361: PMID: 30093605
- High PKD2 predicts poor prognosis in lung adenocarcinoma via promoting Epithelial-mesenchymal Transition. | Pang, Z., et al. 2019. Sci Rep. 9: 1324. PMID: 30718593
- PKD2/polycystin-2 induces autophagy by forming a complex with BECN1. | Peña-Oyarzun, D., et al. 2021. Autophagy. 17: 1714-1728. PMID: 32543276
- PKD2 deficiency suppresses amino acid biosynthesis in ADPKD by impairing the PERK-TBL2-eIF2ɑ-ATF4 pathway. | Zhou, X., et al. 2021. Biochem Biophys Res Commun. 561: 73-79. PMID: 34015761
- Circ-PKD2 promotes Atg13-mediated autophagy by inhibiting miR-646 to increase the sensitivity of cisplatin in oral squamous cell carcinomas. | Gao, L., et al. 2022. Cell Death Dis. 13: 192. PMID: 35220397
- PKD1 and PKD2 mRNA cis-inhibition drives polycystic kidney disease progression. | Lakhia, R., et al. 2022. Nat Commun. 13: 4765. PMID: 35965273
- Identified eleven exon variants in PKD1 and PKD2 genes that altered RNA splicing by minigene assay. | Liu, X., et al. 2023. BMC Genomics. 24: 407. PMID: 37468838
- Pkd2 Deficiency in Embryonic Aqp2 + Progenitor Cells Is Sufficient to Cause Severe Polycystic Kidney Disease. | Tsilosani, A., et al. 2024. J Am Soc Nephrol. 35: 398-409. PMID: 38254271
- Comprehensive Analysis of PKD1 and PKD2 by Long-Read Sequencing in Autosomal Dominant Polycystic Kidney Disease. | Xu, D., et al. 2024. Clin Chem. 70: 841-854. PMID: 38527221
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PKD2 Antibody (431.2) | sc-100415 | 50 µg/0.5 ml | $333.00 |