PP2A-Cα/β Antibody (C-1): sc-376673

PP2A-Cα/β Antibody (C-1) is a mouse monoclonal IgG1 antibody that detects PP2A-Cα/β in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PP2A-Cα/β is a critical component of the protein phosphatase 2A (PP2A) family, which plays a vital role in cellular signaling by dephosphorylating serine and threonine residues on target proteins, thereby regulating various cellular processes including cell division, apoptosis, and metabolic homeostasis. The structure of PP2A is particularly important as PP2A forms a trimeric complex composed of a catalytic subunit, a regulatory subunit, and a variable subunit, which together create a highly versatile enzyme capable of interacting with numerous substrates. This structural complexity allows PP2A to modulate a wide array of signaling pathways, making PP2A essential for maintaining cellular function and responding to external stimuli. The ability of PP2A to form different holoenzyme configurations through regulatory subunits, such as PP2A-Aα and PP2A-B56α, further enhances functional diversity, allowing PP2A to fine-tune cellular responses and maintain homeostasis. Anti-PP2A-Cα/β antibody (C-1) is therefore an invaluable tool for researchers studying the intricate roles of protein phosphatases in health and disease.

The preferred p-PP2A-Cα/β antibody is p-PP2A-Cα/β Antibody (F-8): sc-271903.