PYK2 Antibody (5E2D5): sc-130077

PYK2 Antibody (5E2D5) is a mouse monoclonal IgG2a antibody that detects PYK2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). PYK2, also known as proline-rich tyrosine kinase 2, plays a crucial role in cellular signaling, particularly in the central nervous system, where PYK2 is highly expressed. PYK2 is involved in the modulation of ion channel function and the activation of the mitogen-activated protein kinase (MAPK) signaling pathway, which is essential for various cellular processes, including growth, differentiation, and response to stress. The activation of PYK2 occurs rapidly in response to stimuli that elevate intracellular calcium levels, as well as through the action of phorbol esters that activate protein kinase C (PKC) family members. Notably, PYK2 undergoes significant post-translational modifications, including phosphorylation on tyrosine residues, which are critical for function and regulation. The unique structural organization of PYK2, with a high degree of sequence identity to focal adhesion kinase (FAK), underscores PYK2′s importance in cellular signaling networks and highlights PYK2′s potential as a therapeutic target in various diseases. Anti-PYK2 antibody (5E2D5) is an invaluable tool for researchers investigating the intricate roles of this kinase in human health and disease.

The preferred p-PYK2 antibody is p-PYK2 Antibody (13.Tyr 402): sc-293142.