p-Raf-1 Antibody (6B4): sc-81513
- p-Raf-1 Antibody (6B4) is a mouse monoclonal IgG2a, cited in 5 publications, provided at 50 µg/0.5 ml
- raised against a synthetic phosphopeptide corresponding to amino acid residues surrounding serine 621 of Raf-1 of human origin
- recommended for detection of Ser 621 phosphorylated Raf-1 of mouse, rat and human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for p-Raf-1 Antibody (6B4). This work is in progress.
p-Raf-1 Antibody (6B4) is a mouse monoclonal IgG2a antibody that detects p-Raf-1 in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). p-Raf-1 is a critical regulator in the MAPK signaling pathway, primarily functioning as a serine/threonine kinase that plays a pivotal role in cell proliferation, differentiation, and survival. p-Raf-1 transduces signals from activated receptor tyrosine kinases, leading to the activation of downstream effectors like MEK and ERK, ultimately influencing cellular responses to growth factors and stress signals. p-Raf-1 undergoes several post-translational modifications, including phosphorylation at specific serine and tyrosine residues, which are essential for activation and function. Phosphorylation at Ser 338 is crucial for catalytic activity, while phosphorylation at Ser 621 is necessary for full activation. Phosphorylation of p-Raf-1 by protein kinase A (PKA) can inhibit activity, showcasing the intricate regulatory mechanisms that control function. anti-p-Raf-1 antibody (6B4) serves as an invaluable tool for researchers studying the dynamics of the Raf-1 signaling pathway and its implications in various physiological and pathological processes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-Raf-1 Antibody (6B4) | sc-81513 | 50 µg/0.5 ml | $316.00 |