BMP-3 Antibody (C-9): sc-390046

BMP-3 Antibody (C-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects BMP-3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BMP-3 (C-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Bone morphogenic proteins (BMPs), which belong to the TGFβ superfamily, play a crucial role in regulating bone and cartilage formation, making BMPs essential for skeletal development and repair. BMP-3 has been shown to inhibit excessive bone formation, thus maintaining a balance in bone homeostasis. This regulatory function is vital, as dysregulation of BMP signaling can lead to various skeletal disorders, including osteoarthritis and osteoporosis. BMP-3 interacts with other BMPs, such as BMP-2 and BMP-4, which promote cartilage formation, highlighting the intricate network of signaling pathways that govern skeletal development. BMP-3′s ability to modulate these interactions underscores its importance in both developmental biology and potential therapeutic applications.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

BMP-3 Antibody (C-9) References:

1. Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis.  |  Ozkaynak, E., et al. 1992. J Biol Chem. 267: 25220-7. PMID: 1460021
2. The transforming growth factor-beta family.  |  Massagué, J. 1990. Annu Rev Cell Biol. 6: 597-641. PMID: 2177343
3. Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone.  |  Celeste, AJ., et al. 1990. Proc Natl Acad Sci U S A. 87: 9843-7. PMID: 2263636
4. Novel regulators of bone formation: molecular clones and activities.  |  Wozney, JM., et al. 1988. Science. 242: 1528-34. PMID: 3201241
5. Recombinant Vgr-1/BMP-6-expressing tumors induce fibrosis and endochondral bone formation in vivo.  |  Gitelman, SE., et al. 1994. J Cell Biol. 126: 1595-609. PMID: 8089189
6. A human Mad protein acting as a BMP-regulated transcriptional activator.  |  Liu, F., et al. 1996. Nature. 381: 620-3. PMID: 8637600
7. Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.  |  Zhang, Y., et al. 1996. Nature. 383: 168-72. PMID: 8774881
8. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member.  |  McPherron, AC., et al. 1997. Nature. 387: 83-90. PMID: 9139826

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BMP-3 Antibody (C-9) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-BMP-3 Antibody (C-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

BMP-3 Antibody (C-9) Specifications

Alternate Product Name: BMP-3

Product Clone Name: C-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 363-435

Epitope Target: BMP-3

Epitope Species: human

Product Reactivity/Detection: precursor and mature BMP-3 and BMP-3b

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for BMP-3 Antibody (C-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin