BMP-2/4 Antibody (H-1): sc-137087

BMP-2/4 Antibody (H-1) is a mouse monoclonal IgG2a kappa light chain antibody that detects BMP-2/4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BMP-2/4 Antibody (H-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. BMP-2/4 plays a crucial role in bone and cartilage development, acting as a signaling molecule that regulates cellular proliferation and differentiation. BMP-2/4 is primarily located in the extracellular matrix and is secreted by various cell types, which is essential for mediating the bone morphogenetic protein (BMP) signaling pathway. This pathway is vital for proper formation of bone and cartilage, and dysregulation can lead to various skeletal disorders. BMP-2/4 interacts with specific receptors, including type I and type II receptors, which possess intrinsic serine/threonine kinase activity, initiating a cascade of intracellular signaling events. Understanding BMP-2/4 localization and function is important for elucidating its role in developmental biology and potential therapeutic applications in regenerative medicine and tissue engineering.

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BMP-2/4 Antibody (H-1) References:

1. Osteogenic protein-2. A new member of the transforming growth factor-beta superfamily expressed early in embryogenesis.  |  Ozkaynak, E., et al. 1992. J Biol Chem. 267: 25220-7. PMID: 1460021
2. The transforming growth factor-beta family.  |  Massagué, J. 1990. Annu Rev Cell Biol. 6: 597-641. PMID: 2177343
3. Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone.  |  Celeste, AJ., et al. 1990. Proc Natl Acad Sci U S A. 87: 9843-7. PMID: 2263636
4. Association Between BMP-2 and Carcinogenicity.  |  Skovrlj, B., et al. 2015. Spine (Phila Pa 1976). 40: 1862-71. PMID: 26274524
5. BMP-2-induced bone formation and neural inflammation.  |  Nguyen, V., et al. 2017. J Orthop. 14: 252-256. PMID: 28367006
6. Endogenous BMP-4/ROS/COX-2 Mediated IPC and Resveratrol Alleviated Brain Damage.  |  Yan, Y., et al. 2019. Curr Pharm Des. 25: 1030-1039. PMID: 31113339
7. Novel regulators of bone formation: molecular clones and activities.  |  Wozney, JM., et al. 1988. Science. 242: 1528-34. PMID: 3201241
8. The Roles of GDF-9, BMP-15, BMP-4 and EMMPRIN in Folliculogenesis and In Vitro Fertilization.  |  Fountas, S., et al. 2024. J Clin Med. 13: PMID: 38999341
9. Recombinant Vgr-1/BMP-6-expressing tumors induce fibrosis and endochondral bone formation in vivo.  |  Gitelman, SE., et al. 1994. J Cell Biol. 126: 1595-609. PMID: 8089189
10. A human Mad protein acting as a BMP-regulated transcriptional activator.  |  Liu, F., et al. 1996. Nature. 381: 620-3. PMID: 8637600
11. Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.  |  Zhang, Y., et al. 1996. Nature. 383: 168-72. PMID: 8774881
12. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member.  |  McPherron, AC., et al. 1997. Nature. 387: 83-90. PMID: 9139826

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BMP-2/4 Antibody (H-1) has 46 citations in a variety of scientific publications.

Primary antibodies like Anti-BMP-2/4 Antibody (H-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

BMP-2/4 Antibody (H-1) Specifications

Alternate Product Name: BMP-2/4

Product Clone Name: H-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 300-350

Epitope Target: BMP-2/4

Epitope Species: human

Product Reactivity/Detection: precursor and mature BMP-2 and BMP-4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 46 citations in various scientific publications

Available Conjugates/Forms for BMP-2/4 Antibody (H-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred BMP-4 antibody is BMP-4 Antibody (3H2.3): sc-12721.