HGFα Antibody (H-10): sc-374422
- HGFα Antibody (H-10) is a mouse monoclonal IgG1 κ HGFα antibody, cited in 12 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 3-27 at the N-terminus of HGFα of human origin
- HGF alpha Antibody (H-10) is recommended for detection of HGFα of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine and porcine
- Anti-HGF alpha Antibody (H-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of HGFα (H-10): sc-374422.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for HGFα Antibody (H-10) for WB and IHC(P) applications. These reagents are now offered in bundles with HGFα Antibody (H-10) (see ordering information below).
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HGFα Antibody (H-10) is a mouse monoclonal IgG1 kappa light chain antibody designed to detect hepatocyte growth factor alpha (HGFα), also known as scatter factor, hematopoietin A, or mammary growth factor. HGFα is a vital component of the hepatocyte growth factor (HGF) protein, which plays a crucial role in various cellular processes including cell growth, motility, and morphogenesis. HGFα interacts directly with the c-Met receptor, a receptor tyrosine kinase, to initiate signaling pathways that are essential for liver regeneration, wound healing, and embryonic development. Additionally, HGFα is involved in tissue repair and regeneration by promoting angiogenesis and influencing the behavior of epithelial and endothelial cells. anti-HGFα antibody (H-10) is raised against a specific epitope mapping between amino acids 3-27 at the N-terminus of human HGFα, ensuring high specificity and affinity for the target protein. HGFα monoclonal antibody (H-10) is validated for use in multiple applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA), and demonstrates reactivity with HGFα from various species such as mouse, rat, human, equine, canine, and porcine. By enabling precise detection and quantification of HGFα, anti-HGFα antibody (H-10) facilitates the study of HGF-mediated signaling mechanisms and their implications in both normal physiological processes and pathological conditions like cancer, where HGFα can contribute to tumor growth and metastasis. This makes HGFα (H-10) antibody an indispensable tool for researchers aiming to elucidate the complex functions of HGFα and develop targeted therapeutic strategies, thereby advancing our understanding of its impact on health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HGFα Antibody (H-10) References:
- HGF/SF: a potent cytokine for mammary growth, morphogenesis and development. | Niranjan, B., et al. 1995. Development. 121: 2897-908. PMID: 7555716
- Biological activation of pro-HGF (hepatocyte growth factor) by urokinase is controlled by a stoichiometric reaction. | Naldini, L., et al. 1995. J Biol Chem. 270: 603-11. PMID: 7822285
- The Met/HGF receptor is over-expressed in human osteosarcomas and is activated by either a paracrine or an autocrine circuit. | Ferracini, R., et al. 1995. Oncogene. 10: 739-49. PMID: 7862451
- Proteolytic activation of hepatocyte growth factor in response to tissue injury. | Miyazawa, K., et al. 1994. J Biol Chem. 269: 8966-70. PMID: 8132634
- Coexpression of hepatocyte growth factor and receptor (Met) in human breast carcinoma. | Tuck, AB., et al. 1996. Am J Pathol. 148: 225-32. PMID: 8546209
- Expression and maturation of the cellular sea receptor, a member of the hepatocyte growth factor (HGF) receptor family of protein tyrosine kinases. | Huff, JL., et al. 1996. Oncogene. 12: 299-307. PMID: 8570207
- A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor. | Maestrini, E., et al. 1996. Proc Natl Acad Sci U S A. 93: 674-8. PMID: 8570614
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HGFα Antibody (H-10) | sc-374422 | 200 µg/ml | $316.00 | |||
HGFα Antibody (H-10): m-IgG Fc BP-HRP Bundle | sc-529741 | 200 µg Ab; 10 µg BP | $354.00 | |||
HGFα Antibody (H-10): m-IgGκ BP-HRP Bundle | sc-522733 | 200 µg Ab, 40 µg BP | $354.00 | |||
HGFα Antibody (H-10): m-IgG1 BP-HRP Bundle | sc-543663 | 200 µg Ab; 20 µg BP | $354.00 | |||
HGFα Antibody (H-10) AC | sc-374422 AC | 500 µg/ml, 25% agarose | $416.00 | |||
HGFα Antibody (H-10) HRP | sc-374422 HRP | 200 µg/ml | $316.00 | |||
HGFα Antibody (H-10) FITC | sc-374422 FITC | 200 µg/ml | $330.00 | |||
HGFα Antibody (H-10) PE | sc-374422 PE | 200 µg/ml | $343.00 | |||
HGFα Antibody (H-10) Alexa Fluor® 488 | sc-374422 AF488 | 200 µg/ml | $357.00 | |||
HGFα Antibody (H-10) Alexa Fluor® 546 | sc-374422 AF546 | 200 µg/ml | $357.00 | |||
HGFα Antibody (H-10) Alexa Fluor® 594 | sc-374422 AF594 | 200 µg/ml | $357.00 | |||
HGFα Antibody (H-10) Alexa Fluor® 647 | sc-374422 AF647 | 200 µg/ml | $357.00 | |||
HGFα Antibody (H-10) Alexa Fluor® 680 | sc-374422 AF680 | 200 µg/ml | $357.00 | |||
HGFα Antibody (H-10) Alexa Fluor® 790 | sc-374422 AF790 | 200 µg/ml | $357.00 | |||
HGFα (H-10) Neutralizing Peptide | sc-374422 P | 100 µg/0.5 ml | $68.00 |