IFN-α Antibody (5D4): sc-80996

IFN-α Antibody (5D4) is a mouse monoclonal IgG1 antibody that detects interferon-alpha (IFN-α) in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). IFN-α plays a crucial role in the immune response, particularly in the defense against viral infections, by inducing the expression of various antiviral proteins and enhancing the activity of immune cells. This cytokine is produced primarily by leukocytes in response to viral infections and is essential for establishing an effective antiviral state in neighboring cells, thereby limiting viral replication and spread. The importance of IFN-α extends beyond its antiviral properties, as IFN-α also exhibits antitumor and immunomodulatory effects, making IFN-α a valuable therapeutic agent in the treatment of various malignancies and autoimmune diseases. The IFN-α receptor, a multisubunit complex, facilitates the signaling of IFN-α, leading to the activation of several downstream pathways that contribute to its diverse biological functions. With an ability to target and modulate immune responses, IFN-α remains a significant focus of research and clinical application, underscoring the relevance of anti-IFN-α antibody (5D4) in studying and harnessing the power of this vital cytokine.

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IFN-α Antibody (5D4) References:

1. IFN-α in the treatment of melanoma.  |  Tarhini, AA., et al. 2012. J Immunol. 189: 3789-93. PMID: 23042723
2. IFN-α subtypes: distinct biological activities in anti-viral therapy.  |  Gibbert, K., et al. 2013. Br J Pharmacol. 168: 1048-58. PMID: 23072338
3. IFN-α induces IL-10 production and tilt the balance between Th1 and Th17 in Behçet disease.  |  Touzot, M., et al. 2015. Autoimmun Rev. 14: 370-5. PMID: 25541082
4. The Role of IFN-alpha in Experimental and Clinical Uveitis.  |  Liu, X., et al. 2019. Ocul Immunol Inflamm. 27: 23-33. PMID: 28375033
5. Control of HIV infection by IFN-α: implications for latency and a cure.  |  Bourke, NM., et al. 2018. Cell Mol Life Sci. 75: 775-783. PMID: 28988399
6. Potential role of IFN-α in COVID-19 patients and its underlying treatment options.  |  Yang, L., et al. 2021. Appl Microbiol Biotechnol. 105: 4005-4015. PMID: 33950278
7. IFN-α: A key therapeutic target for multiple autoimmune rheumatic diseases.  |  De Ceuninck, F., et al. 2021. Drug Discov Today. 26: 2465-2473. PMID: 34224903
8. Infection courses, virological features and IFN-α responses of HBV genotypes in cell culture and animal models.  |  Zhang, M., et al. 2021. J Hepatol. 75: 1335-1345. PMID: 34363922
9. Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19.  |  Krämer, B., et al. 2021. Immunity. 54: 2650-2669.e14. PMID: 34592166
10. Role of IFN-α in Rheumatoid Arthritis.  |  Lin, CMA., et al. 2024. Curr Rheumatol Rep. 26: 37-52. PMID: 38051494

The preferred IFN-α antibody is IFN-α Antibody (F-7): sc-373757.