IFN-α1/2/13 Antibody (ST29): sc-53341

IFN-α1/2/13 Antibody (ST29) is a mouse monoclonal IgG1 kappa light chain antibody that detects the IFN-alpha 1/2/13 protein of human origin by functional assay. Anti-IFN-alpha 1/2/13 antibody (ST29) is available as the non-conjugated format. Type I interferons, including IFN-α1, IFN-α2, and IFN-α13, play a crucial role in immune response, particularly in defense against viral infections. These cytokines are produced by various cells in response to viral pathogens and are essential for activating immune cells, enhancing antiviral state of neighboring cells, and modulating adaptive immune response. IFN-α1/2/13 induces expression of numerous genes involved in antiviral defense, such as those coding for proteins that inhibit viral replication, underscoring its importance in both innate and adaptive immunity. Genes encoding type I interferons are clustered on human chromosome 9, facilitating coordinated regulation and expression in response to infections. Type I interferon receptor (IFN-αR) interacts with these cytokines, highlighting intricate signaling pathways that govern immune responses.

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IFN-α1/2/13 Antibody (ST29) References:

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2. Expression of interferon-alpha (IFN-alpha) receptor 2c at diagnosis is associated with cytogenetic response in IFN-alpha-treated chronic myeloid leukemia.  |  Barthe, C., et al. 2001. Blood. 97: 3568-73. PMID: 11369652
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4. Up-regulation of the interferon gamma (IFN-gamma)-inducible chemokines IFN-inducible T-cell alpha chemoattractant and monokine induced by IFN-gamma and of their receptor CXC receptor 3 in human renal cell carcinoma.  |  Suyama, T., et al. 2005. Cancer. 103: 258-67. PMID: 15578685
5. Antigenic structure of human interferon omega 1 (interferon alpha II1): comparison with other human interferons.  |  Adolf, GR. 1987. J Gen Virol. 68 (Pt 6): 1669-76. PMID: 2438379
6. Transient Increase of Pre-existing Anti-IFN-α2 Antibodies Induced by SARS-CoV-2 Infection.  |  Steels, S., et al. 2022. J Clin Immunol. 42: 742-745. PMID: 35296990
7. Pretreatment of UC-MSCs with IFN-α2 improves treatment of liver fibrosis by recruiting neutrophils.  |  Xie, Y., et al. 2023. J Transl Med. 21: 832. PMID: 37980535
8. Schlafen Family Intra-Regulation by IFN-α2 in Triple-Negative Breast Cancer.  |  Brown, SR., et al. 2023. Cancers (Basel). 15: PMID: 38067362
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10. An anti-cytokine bioactivity assay for interferons-alpha, -beta and -omega.  |  Mire-Sluis, AR., et al. 1996. J Immunol Methods. 195: 55-61. PMID: 8814320
11. Identification of interferon-alpha 7, -alpha 14, and -alpha 21 variants in the genome of a large human population.  |  Hussain, M., et al. 1996. J Interferon Cytokine Res. 16: 853-9. PMID: 8910771
12. Contributions of cloned type I interferon receptor subunits to differential ligand binding.  |  Cutrone, EC. and Langer, JA. 1997. FEBS Lett. 404: 197-202. PMID: 9119063

The preferred IFN-α2 antibody is IFN-α2 Antibody (MT4/E4): sc-53342.