IFN-γ/Interferon gamma Antibody (DB-14): sc-59992
- IFN-γ/Interferon gamma Antibody (DB-14) is a mouse monoclonal IgG2a, cited in 9 publications, provided at 100 µg/ml
- raised against IFN-γ of rat origin
- recommended for detection of IFN-γ of mouse and rat origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IFN-γ/Interferon gamma Antibody (DB-14). This work is in progress.
IFN-γ Antibody (DB-14) is a mouse monoclonal IgG2a antibody that detects interferon (IFN)-γ in mouse and rat samples through applications such as western blotting (WB) and immunoprecipitation (IP). IFN-γ plays a crucial role in the immune response, acting as a potent antiviral and antiparasitic agent produced by activated CD4+/CD8+ lymphocytes and natural killer cells. IFN-γ modulates T cell growth and differentiation while inhibiting B cell proliferation, thereby shaping the adaptive immune response. The active form of IFN-γ is a homodimer, with each subunit comprising six helices, and this dimeric structure is stabilized by non-covalent interactions at the interface of the helices. The precursor of IFN-γ consists of 166 amino acids, which includes a 23 amino acid secretory sequence, and IFN-γ functionality is further influenced by post-translational modifications such as glycosylation, leading to multiple forms under non-denaturing conditions, including dimers and tetramers. The versatility of IFN-γ in immune regulation underscores its significance in therapeutic applications and research, making anti-IFN-γ antibody (DB-14) an essential tool for studying immune responses in various biological contexts.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IFN-γ/Interferon gamma Antibody (DB-14) | sc-59992 | 100 µg/ml | $316.00 |