IFN-γ/Interferon gamma Antibody (XMG1.2): sc-52557

IFN-γ Antibody (XMG1.2) is a rat monoclonal IgG1 antibody that detects interferon gamma (IFN-γ) in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). IFN-γ plays a crucial role in the immune response, acting as a potent antiviral and antiparasitic agent produced by activated CD4+/CD8+ lymphocytes and natural killer cells. Anti-IFN-γ antibody (XMG1.2) recognizes a protein that modulates T cell growth and differentiation while inhibiting B cell proliferation, thereby shaping the adaptive immune response. IFN-γ is primarily located in the cytoplasm and secreted into the extracellular space, where IFN-γ exerts effects on various immune cells. The active form of IFN-γ is a homodimer, with each subunit comprising six helices, and this dimeric structure is stabilized by non-covalent interactions at the interface of the helices. The precursor of IFN-γ consists of 166 amino acids, including a 23 amino acid secretory sequence, and IFN-γ functionality is further influenced by post-translational modifications such as glycosylation, which can lead to the formation of multiple isoforms under non-denaturing conditions, including dimers and tetramers. IFN-γ monoclonal antibody (XMG1.2) is an essential tool for researchers studying immune responses and the mechanisms of action of this vital cytokine.

The preferred IFN-γ/Interferon gamma antibody is IFN-γ/Interferon gamma Antibody (G-23): sc-8423.