IL-2 Antibody (I2t-C7): sc-57285

IL-2 Antibody (I2t-C7) is a rat monoclonal IgG antibody that detects IL-2 of mouse origin by enzyme-linked immunosorbent assay (ELISA). Anti-IL-2 antibody (I2t-C7) is available as the non-conjugated form. IL-2, or Interleukin 2, is a crucial lymphokine primarily secreted by activated helper T cells, playing a vital role in the immune response by promoting the proliferation of T cells and acting as a growth factor for B cells. IL-2 enhances the immune system′s response to pathogens and tumors, making IL-2 a key player in immunotherapy and vaccine development. IL-2 function is intricately linked to signaling pathways, which include three distinct IL-2-dependent pathways: the c-Fos/c-Jun induction pathway mediated by Src family protein-tyrosine kinases, the c-Myc induction pathway, and the Rapamycin-sensitive pathway, all culminating in the induction of Bcl-2, a protein that helps regulate cell survival. Additionally, the transcription factor NFAT is essential for IL-2 transcription regulation, and NFAT activity has been shown to decline with age, correlating with reduced IL-2 expression. IL-2 serves as both a marker of immune activation and a potential target for therapeutic interventions aimed at enhancing immune function in aging populations.

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IL-2 Antibody (I2t-C7) References:

1. IL-2 and autoimmune disease.  |  Schimpl, A., et al. 2002. Cytokine Growth Factor Rev. 13: 369-78. PMID: 12220550
2. Components of an antigen-/T cell receptor-independent pathway of lymphokine production.  |  Germann, T., et al. 1991. Eur J Immunol. 21: 1857-61. PMID: 1907919
3. Lymphokine signal transduction.  |  Guy, GR., et al. 1990. Prog Growth Factor Res. 2: 45-70. PMID: 2129510
4. Modulation of T cell responses by IL-2 and IL-2 complexes.  |  Boyman, O., et al. 2015. Clin Exp Rheumatol. 33: S54-7. PMID: 26457438
5. Biology of IL-2 and its therapeutic modulation: Mechanisms and strategies.  |  Mitra, S. and Leonard, WJ. 2018. J Leukoc Biol. 103: 643-655. PMID: 29522246
6. Engineering IL-2 to Give New Life to T Cell Immunotherapy.  |  Overwijk, WW., et al. 2021. Annu Rev Med. 72: 281-311. PMID: 33158368
7. Similarities between interleukin-2 receptor number and affinity on activated B and T lymphocytes.  |  Lowenthal, JW., et al. Nature. 315: 669-72. PMID: 3925347
8. Structure and expression of a cloned cDNA for human interleukin-2.  |  Taniguchi, T., et al. Nature. 302: 305-10. PMID: 6403867
9. T-cell growth factor.  |  Smith, KA. 1980. Immunol Rev. 51: 337-57. PMID: 7000676
10. The age-related decline in the induction of IL-2 transcription is correlated to changes in the transcription factor NFAT.  |  Pahlavani, MA., et al. 1995. Cell Immunol. 165: 84-91. PMID: 7671328
11. Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation.  |  Miyazaki, T., et al. 1995. Cell. 81: 223-31. PMID: 7736574
12. Contribution of p56lck to the upregulation of cytokine production and T cell proliferation by IL-2 in human CD3-stimulated T cell clones.  |  Eljaafari, A., et al. 1995. Cell Immunol. 160: 152-6. PMID: 7842481

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IL-2 Antibody (I2t-C7) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-IL-2 Antibody (I2t-C7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IL-2 Antibody (I2t-C7) Specifications

Alternate Product Name: Interleukin 2

Product Clone Name: I2t-C7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG

Amino Acids:

Epitope Target: IL-2

Epitope Species: mouse

Product Reactivity/Detection: IL-2

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: ELISA

Vialing Information: Each vial contains 100 µg IgG in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for IL-2 Antibody (I2t-C7): N/A