beta 2 Adrenergic Receptor/ADRB2/β2-AR Antibody (I3D6): sc-81578

β2-AR Antibody (I3D6) is a mouse monoclonal IgG1 antibody that detects β2-adrenergic receptor (β2-AR) in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). β2-AR plays a crucial role in mediating the physiological effects of catecholamines such as epinephrine and norepinephrine, which are vital for regulating numerous bodily functions including cardiac output, smooth muscle relaxation, and metabolic processes. The receptor is predominantly located on the cell surface, where β2-AR interacts with heterotrimeric G proteins to initiate intracellular signaling cascades that influence heart rate and vascular tone. This localization is essential as β2-AR allows for rapid responses to hormonal signals, ensuring that the body can adapt to stress and maintain homeostasis. β2-AR undergoes post-translational modifications, such as phosphorylation, which can modulate activity and desensitization, further emphasizing the importance of regulation in various physiological contexts. Through forming signaling complexes with other proteins, including calcium channels and kinases, β2-AR is integral to the intricate network of cellular communication that governs cardiovascular and metabolic health.

The preferred beta 2 Adrenergic Receptor/ADRB2/β2-AR antibody is beta 2 Adrenergic Receptor/ADRB2/β2-AR Antibody (R11E1): sc-81577.