BMPR-II Antibody (Z-18): sc-73752
- BMPR-II Antibody (Z-18) is a mouse monoclonal IgG2b provided at 100 µg/ml
- raised against the extracellular domain of BMPR-II of human origin
- recommended for detection of BMPR-II of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for BMPR-II Antibody (Z-18). This work is in progress.
BMPR-II Antibody (Z-18) is a mouse monoclonal IgG2b antibody that detects BMPR-II in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). BMPR-II, a member of the transforming growth factor β superfamily, plays a crucial role in cellular signaling by forming a complex with type I receptors, which are essential for mediating the effects of bone morphogenetic proteins (BMPs) on gene expression, cell differentiation, and morphogenesis. BMPR-II is primarily located on the cell surface, where BMPR-II interacts with BMPs, including OP-1 and BMP-2, to initiate downstream signaling pathways that influence various biological processes. Proper functioning of BMPR-II is vital, as dysregulation has been implicated in several pathologies, including cancer and fibrotic diseases. Additionally, BMPR-II undergoes post-translational modifications, such as phosphorylation, which can affect activity and stability, further underscoring BMPR-II′s importance in maintaining cellular homeostasis. Anti-BMPR-II antibody (Z-18) is an invaluable tool for researchers studying the intricate signaling mechanisms of BMPs and their implications in health and disease.
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BMPR-II Antibody (Z-18) References:
- TGF-beta and BMPR-II pharmacology--implications for pulmonary vascular diseases. | Upton, PD. and Morrell, NW. 2009. Curr Opin Pharmacol. 9: 274-80. PMID: 19321386
- BMPR-II is dispensable for formation of the limb skeleton. | Gamer, LW., et al. 2011. Genesis. 49: 719-24. PMID: 21538804
- Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension. | Long, L., et al. 2015. Nat Med. 21: 777-85. PMID: 26076038
- MnTBAP increases BMPR-II expression in endothelial cells and attenuates vascular inflammation. | Zhou, Q., et al. 2016. Vascul Pharmacol. 84: 67-73. PMID: 27401963
- Restoring BMPRII functions in pulmonary arterial hypertension: opportunities, challenges and limitations. | Guignabert, C., et al. 2017. Expert Opin Ther Targets. 21: 181-190. PMID: 28001443
- BMPRII deficiency impairs apoptosis via the BMPRII-ALK1-BclX-mediated pathway in pulmonary arterial hypertension. | Chowdhury, HM., et al. 2019. Hum Mol Genet. 28: 2161-2173. PMID: 30809644
- SPARC-related modular calcium binding 1 regulates aortic valve calcification by disrupting BMPR-II/p-p38 signalling. | Wang, Y., et al. 2022. Cardiovasc Res. 118: 913-928. PMID: 33757126
- Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10. | Guo, J., et al. 2022. Nat Commun. 13: 2395. PMID: 35504921
- Effect of the BMPR-II-SMAD3/MRTF pathway on proliferation and migration of ASMCs and the mechanism in asthma. | Gu, W., et al. 2022. Mol Biol Rep. 49: 9283-9296. PMID: 36008606
- Bone morphogenetic protein signalling in pulmonary arterial hypertension: revisiting the BMPRII connection. | Li, W. and Quigley, K. 2024. Biochem Soc Trans. 52: 1515-1528. PMID: 38716930
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BMPR-II Antibody (Z-18) | sc-73752 | 100 µg/ml | $316.00 |