IGF-IRα Antibody (G-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects IGF-IR alpha in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). IGF-IRα (G-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The insulin-like growth factor-I receptor (IGF-IR) plays a crucial role as a receptor tyrosine kinase, influencing vital cellular processes such as growth, survival, and differentiation. Located on the cell membrane, IGF-IR is activated by insulin-like growth factor-I (IGF-I), which leads to receptor dimerization and autophosphorylation, triggering downstream signaling pathways that include the Ras/ERK and PI3K/Akt pathways. These pathways regulate gene expression and cellular responses to growth signals, making IGF-IR significant in both normal physiology and cancer pathogenesis. The human IGF-IR gene is located on chromosome 15q26.3 and encodes a precursor protein that is cleaved into α and β subunits, highlighting the complexity of structure and function. IGF-IR′s ability to mediate critical growth signals makes anti-IGF-IRα antibody (G-5) valuable for research and clinical applications, particularly in cancer treatment studies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IGF-1 Receptor α/IGF1R Antibody (G-5) | sc-271606 | 200 µg/ml | $316.00 | |||
IGF-1 Receptor α/IGF1R Antibody (G-5): m-IgG Fc BP-HRP Bundle | sc-527264 | 200 µg Ab; 10 µg BP | $354.00 | |||
IGF-1 Receptor α/IGF1R Antibody (G-5): m-IgG1 BP-HRP Bundle | sc-532637 | 200 µg Ab; 20 µg BP | $354.00 | |||
IGF-1 Receptor α/IGF1R Antibody (G-5) AC | sc-271606 AC | 500 µg/ml, 25% agarose | $416.00 | |||
IGF-1 Receptor α/IGF1R Antibody (G-5) HRP | sc-271606 HRP | 200 µg/ml | $316.00 | |||
IGF-1 Receptor α/IGF1R Antibody (G-5) FITC | sc-271606 FITC | 200 µg/ml | $330.00 | |||
IGF-1 Receptor α/IGF1R Antibody (G-5) PE | sc-271606 PE | 200 µg/ml | $343.00 | |||
IGF-1 Receptor α/IGF1R Antibody (G-5) Alexa Fluor® 488 | sc-271606 AF488 | 200 µg/ml | $357.00 | |||
IGF-1 Receptor α/IGF1R Antibody (G-5) Alexa Fluor® 546 | sc-271606 AF546 | 200 µg/ml | $357.00 | |||
IGF-1 Receptor α/IGF1R Antibody (G-5) Alexa Fluor® 594 | sc-271606 AF594 | 200 µg/ml | $357.00 | |||
IGF-1 Receptor α/IGF1R Antibody (G-5) Alexa Fluor® 647 | sc-271606 AF647 | 200 µg/ml | $357.00 | |||
IGF-1 Receptor α/IGF1R Antibody (G-5) Alexa Fluor® 680 | sc-271606 AF680 | 200 µg/ml | $357.00 | |||
IGF-1 Receptor α/IGF1R Antibody (G-5) Alexa Fluor® 790 | sc-271606 AF790 | 200 µg/ml | $357.00 |