OSMR β Antibody (AN-U2): sc-21797
- OSMR β Antibody (AN-U2) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against human OSMRβ transfected COS cells
- recommended for detection of OSMR β of mouse, rat and human origin by WB, IP and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for OSMR β Antibody (AN-U2) for WB applications. These reagents are now offered in bundles with OSMR β Antibody (AN-U2) (see ordering information below).
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OSMR β Antibody (AN-U2) is a mouse monoclonal IgG1 antibody that detects OSMR β in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). OSMR β, also known as oncostatin M receptor β, is a crucial single-pass type I membrane protein composed of 979 amino acids, primarily expressed in neural cells, fibroblasts, and epithelial tumor lines. OSMR β plays a significant role as a receptor for oncostatin M, facilitating the transduction of signaling events that influence cell growth and differentiation. The interaction of OSMR β with interleukins is vital for mediating various biological responses, particularly in the context of immune regulation and inflammation. Importantly, defects in the gene encoding OSMR β can lead to primary cutaneous amyloidosis, an autosomal dominant disorder marked by chronic skin itching, highlighting OSMR β′s relevance in both health and disease. Anti-OSMR β antibody (AN-U2) is an essential tool for researchers investigating the complex signaling pathways involving oncostatin M and its receptor, providing insights into cellular mechanisms and potential therapeutic targets.
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OSMR β Antibody (AN-U2) References:
- Expression of oncostatin M receptor beta in a specific subset of nociceptive sensory neurons. | Tamura, S., et al. 2003. Eur J Neurosci. 17: 2287-98. PMID: 12814362
- Oncostatin M receptor-beta mutations underlie familial primary localized cutaneous amyloidosis. | Arita, K., et al. 2008. Am J Hum Genet. 82: 73-80. PMID: 18179886
- Overexpression of a splice variant of oncostatin M receptor beta in human esophageal squamous carcinoma. | Kausar, T., et al. 2011. Cell Oncol (Dordr). 34: 177-87. PMID: 21394648
- Therapeutic targeting of the oncostatin M receptor-β prevents inflammatory heart failure. | Pöling, J., et al. 2014. Basic Res Cardiol. 109: 396. PMID: 24292852
- Hepatic Oncostatin M Receptor β Regulates Obesity-Induced Steatosis and Insulin Resistance. | Luo, P., et al. 2016. Am J Pathol. 186: 1278-92. PMID: 26976243
- Oncostatin M receptor β deficiency attenuates atherogenesis by inhibiting JAK2/STAT3 signaling in macrophages. | Zhang, X., et al. 2017. J Lipid Res. 58: 895-906. PMID: 28258089
- Essential roles of oncostatin M receptor β signaling in renal crystal formation in mice. | Yamashita, S., et al. 2020. Sci Rep. 10: 17150. PMID: 33051515
- Itch intensity in prurigo nodularis is closely related to dermal interleukin-31, oncostatin M, IL-31 receptor alpha and oncostatin M receptor beta. | Hashimoto, T., et al. 2021. Exp Dermatol. 30: 804-810. PMID: 33428793
- Blockade of OSMRβ signaling ameliorates skin lesions in a mouse model of human atopic dermatitis. | Komori, T., et al. 2024. FASEB J. 38: e23359. PMID: 38102969
- Suppression of renal crystal formation, inflammation, and fibrosis by blocking oncostatin M receptor β signaling. | Deguchi, R., et al. 2024. Sci Rep. 14: 28913. PMID: 39572752
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
OSMR β Antibody (AN-U2) | sc-21797 | 200 µg/ml | $316.00 | |||
OSMR β Antibody (AN-U2): m-IgG Fc BP-HRP Bundle | sc-536677 | 200 µg Ab; 10 µg BP | $354.00 | |||
OSMR β Antibody (AN-U2): m-IgGκ BP-HRP Bundle | sc-533836 | 200 µg Ab; 40 µg BP | $354.00 | |||
OSMR β Antibody (AN-U2): m-IgG1 BP-HRP Bundle | sc-544758 | 200 µg Ab; 20 µg BP | $354.00 | |||
OSMR β Antibody (AN-U2) FITC | sc-21797 FITC | 200 µg/ml | $330.00 | |||
OSMR β Antibody (AN-U2) PE | sc-21797 PE | 200 µg/ml | $343.00 |