ROS-GC1 Antibody (B-7): sc-376217
- ROS-GC1 Antibody (B-7) is a mouse monoclonal IgG2a κ ROS-GC1 antibody, cited in 4 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 1081-1103 at the C-terminus of ROS-GC1 of human origin
- ROS-GC1 Antibody (B-7) is recommended for detection of ROS-GC1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-ROS-GC1 Antibody (B-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of ROS-GC1 (B-7): sc-376217.
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ROS-GC1 Antibody (B-7) for WB applications. These reagents are now offered in bundles with ROS-GC1 Antibody (B-7) (see ordering information below).
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ROS-GC1 Antibody (B-7) is a mouse monoclonal IgG1 antibody that detects ROS-GC1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-ROS-GC1 antibody (B-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ROS-GC1 plays a crucial role in the phototransduction pathway, which is essential for converting light into electrical signals in the retina. ROS-GC1 is localized in the nuclei and inner segments of rod and cone photoreceptor cells, where ROS-GC1 is involved in the regulation of intracellular levels of cyclic guanosine monophosphate (cGMP), a key second messenger in visual signaling. Proper functioning of ROS-GC1 is vital for maintaining photoreceptor health and function; defects in the gene encoding ROS-GC1, GUCY2D, are linked to dominant cone-rod dystrophy type 6 (CORD6), a condition that leads to progressive vision loss. ROS-GC1 monoclonal antibody (B-7) effectively detects ROS-GC1 across multiple species and applications, making this research tool invaluable for studying retinal diseases and the underlying mechanisms of phototransduction.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ROS-GC1 Antibody (B-7) References:
- Guanylate cyclase and the .NO/cGMP signaling pathway. | Denninger, JW. and Marletta, MA. 1999. Biochim Biophys Acta. 1411: 334-50. PMID: 10320667
- A second calcium regulator of rod outer segment membrane guanylate cyclase, ROS-GC1: neurocalcin. | Kumar, VD., et al. 1999. Biochemistry. 38: 12614-20. PMID: 10504230
- Rod outer segment membrane guanylate cyclase type 1-linked stimulatory and inhibitory calcium signaling systems in the pineal gland: biochemical, molecular, and immunohistochemical evidence. | Venkataraman, V., et al. 2000. Biochemistry. 39: 6042-52. PMID: 10821676
- In vivo control of soluble guanylate cyclase activation by nitric oxide: a kinetic analysis. | Condorelli, P. and George, SC. 2001. Biophys J. 80: 2110-9. PMID: 11325714
- Structure and Ca2+ regulation of frog photoreceptor guanylate cyclase, ROS-GC1. | Subbaraya, I., et al. 2003. Mol Cell Biochem. 254: 9-19. PMID: 14674678
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ROS-GC1 Antibody (B-7) | sc-376217 | 200 µg/ml | $316.00 | |||
ROS-GC1 Antibody (B-7): m-IgG Fc BP-HRP Bundle | sc-529838 | 200 µg Ab; 10 µg BP | $354.00 | |||
ROS-GC1 Antibody (B-7): m-IgGκ BP-HRP Bundle | sc-522878 | 200 µg Ab, 40 µg BP | $354.00 | |||
ROS-GC1 Antibody (B-7): m-IgG2a BP-HRP Bundle | sc-547389 | 200 µg Ab; 10 µg BP | $354.00 | |||
ROS-GC1 Antibody (B-7) AC | sc-376217 AC | 500 µg/ml, 25% agarose | $416.00 | |||
ROS-GC1 Antibody (B-7) HRP | sc-376217 HRP | 200 µg/ml | $316.00 | |||
ROS-GC1 Antibody (B-7) FITC | sc-376217 FITC | 200 µg/ml | $330.00 | |||
ROS-GC1 Antibody (B-7) PE | sc-376217 PE | 200 µg/ml | $343.00 | |||
ROS-GC1 Antibody (B-7) Alexa Fluor® 488 | sc-376217 AF488 | 200 µg/ml | $357.00 | |||
ROS-GC1 Antibody (B-7) Alexa Fluor® 546 | sc-376217 AF546 | 200 µg/ml | $357.00 | |||
ROS-GC1 Antibody (B-7) Alexa Fluor® 594 | sc-376217 AF594 | 200 µg/ml | $357.00 | |||
ROS-GC1 Antibody (B-7) Alexa Fluor® 647 | sc-376217 AF647 | 200 µg/ml | $357.00 | |||
ROS-GC1 Antibody (B-7) Alexa Fluor® 680 | sc-376217 AF680 | 200 µg/ml | $357.00 | |||
ROS-GC1 Antibody (B-7) Alexa Fluor® 790 | sc-376217 AF790 | 200 µg/ml | $357.00 | |||
ROS-GC1 (B-7) Neutralizing Peptide | sc-376217 P | 100 µg/0.5 ml | $68.00 |