4.1B Antibody (A-7): sc-514386

4.1B Antibody (A-7) is a mouse monoclonal IgG1 antibody that detects 4.1B in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). 4.1B, also known as EPB41L3, is a member of the 4.1 gene family, which encodes a group of multifunctional cytoskeletal proteins that play critical roles in maintaining cell shape and mechanical properties. 4.1B is predominantly expressed in the brain and is particularly important for its involvement in the stabilization of the spectrin-actin cytoskeleton, which is essential for the structural integrity of neuronal cells. The unique distribution of 4.1B in the cerebellum suggests that 4.1B may modulate the mechanical properties of neuronal membranes, thereby influencing synaptic function and plasticity. Additionally, 4.1B has been shown to interact with other proteins in the postsynaptic density, highlighting 4.1B′s role in synaptic signaling and the maintenance of neuronal architecture. Anti-4.1B antibody (A-7) detects multiple forms of 4.1B, making anti-4.1B antibody (A-7) a valuable tool for researchers studying the dynamics of cytoskeletal interactions and their implications in neurobiology.

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4.1B Antibody (A-7) References:

1. Protein 4.1, a multifunctional protein of the erythrocyte membrane skeleton: structure and functions in erythrocytes and nonerythroid cells.  |  Takakuwa, Y. 2000. Int J Hematol. 72: 298-309. PMID: 11185985
2. Allele-specific loss of heterozygosity at the DAL-1/4.1B (EPB41L3) tumor-suppressor gene locus in the absence of mutation.  |  Kittiniyom, K., et al. 2004. Genes Chromosomes Cancer. 40: 190-203. PMID: 15138999
3. Promoter hypermethylation of the potential tumor suppressor DAL-1/4.1B gene in renal clear cell carcinoma.  |  Yamada, D., et al. 2006. Int J Cancer. 118: 916-23. PMID: 16152585
4. An interaction between {alpha}v{beta}8 integrin and Band 4.1B via a highly conserved region of the Band 4.1 C-terminal domain.  |  McCarty, JH., et al. 2005. Proc Natl Acad Sci U S A. 102: 13479-83. PMID: 16157875
5. Protein 4.1 expression in the developing hair cells of the mouse inner ear.  |  Okumura, K., et al. 2010. Brain Res. 1307: 53-62. PMID: 19853587
6. Organization of myelinated axons by Caspr and Caspr2 requires the cytoskeletal adapter protein 4.1B.  |  Horresh, I., et al. 2010. J Neurosci. 30: 2480-9. PMID: 20164332
7. A 130-kDa protein 4.1B regulates cell adhesion, spreading, and migration of mouse embryo fibroblasts by influencing actin cytoskeleton organization.  |  Wang, J., et al. 2014. J Biol Chem. 289: 5925-37. PMID: 24381168
8. Comprehensive characterization of protein 4.1 expression in epithelium of large intestine.  |  Zhang, J., et al. 2014. Histochem Cell Biol. 142: 529-39. PMID: 24912669
9. Assembly of juxtaparanodes in myelinating DRG culture: Differential clustering of the Kv1/Caspr2 complex and scaffolding protein 4.1B.  |  Hivert, B., et al. 2016. Glia. 64: 840-52. PMID: 26840208
10. Correction: A Golgi-associated protein 4.1B variant is required for assimilation of proteins in the membrane (doi:10.1242/jcs.039644).  |  Kang, Q., et al. 2019. J Cell Sci. 132: PMID: 31636159

The preferred 4.1B antibody is 4.1B Antibody (B-6): sc-398089.