4.1N Antibody (B-7): sc-374368

4.1N Antibody (B-7) is a mouse monoclonal IgG2b antibody that detects 4.1N protein in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). 4.1N, also known as band 4.1-like protein 1 or neuronal protein 4.1, plays a crucial role in binding and stabilizing D2 and D3 dopamine receptors at the neuronal plasma membrane, which is essential for maintaining proper neurotransmission and neuronal signaling. 4.1N protein is predominantly expressed in the brain, where anti-4.1N antibody (B-7) contributes to studying structural integrity and plasticity of neuronal membranes by mediating interactions between the cytoskeleton and plasma membrane. 4.1N protein is present at lower levels in heart, kidney, pancreas, placenta, lung, and skeletal muscle, indicating diverse functional roles across different organ systems. The complexity of 4.1N is further highlighted by the existence of four homologous genes (4.1R, 4.1G, 4.1N, and 4.1B), which undergo intricate alternative splicing, suggesting these spliced variants may be involved in targeted regulation of specific transmembrane proteins, particularly in kidney epithelium, thereby influencing various kidney functions. With multifaceted roles in cellular architecture and signaling, 4.1N monoclonal antibody (B-7) serves as an invaluable tool for researchers investigating neuronal function and related pathologies.

The preferred 4.1N antibody is 4.1N Antibody (B-2): sc-374367.