NMDA Receptor 2B (GluN2B) (D15B3) Rabbit mAb #4212
- WB
To Purchase # 4212
| Cat. # | Size | Qty. | Price |
|---|---|---|---|
| 4212T | 20 µl | $153 | |
| 4212S | 100 µl | $339 |
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 190 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
- Related Products
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Simple Western™ | 1:10 - 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
EphrinB2 binding to the receptor EphB leads to the activation of Src family tyrosine kinases, which phosphorylate NMDAR2B at Tyr1252, Tyr1336 and Tyr1472. In turn, phosphorylated NMDAR2B enhances the ability of the functional NMDA receptor to regulate Ca2+ influx in response to glutamate (7).
- Liu, X.B. et al. (2004) J Neurosci 24, 8885-95.
- Westphal, R.S. et al. (1999) Science 285, 93-6.
- Tingley, W.G. et al. (1997) J Biol Chem 272, 5157-66.
- Hisatsune, C. et al. (1997) J Biol Chem 272, 20805-10.
- Raman, I.M. et al. (1996) Neuron 16, 415-21.
- Makhinson, M. et al. (1999) J Neurosci 19, 2500-10.
- Takasu, M.A. et al. (2002) Science 295, 491-495.
- Devi, L. and Ohno, M. (2015) Transl Psychiatry 5, e562.
Alternate Names
NMDAR; NR2
Pathways
Explore pathways related to this product.
Limited Uses
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