p-caveolin-1 Antibody (B-9): sc-373837

p-caveolin-1 Antibody (B-9) is a mouse monoclonal IgG2b kappa light chain antibody that detects the Tyr 14 phosphorylated caveolin-1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-p-caveolin-1 antibody (B-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Caveolin-1 plays a crucial role in the formation of caveolae, which are specialized flask-shaped invaginations of the plasma membrane that facilitate the transcytosis of macromolecules and the compartmentalization of signaling molecules. These structures are essential for cellular processes such as the uptake of small molecules and the regulation of signaling pathways involving G protein-coupled receptors. Caveolin-1, along with caveolin-2 and caveolin-3, forms the core components of caveolae, and phosphorylation at Tyr 14 is particularly significant as this modification is involved in growth factor signaling and is constitutively active in transformed cells. The interaction of caveolin-1 with various heterotrimeric G protein isoforms further underscores p-caveolin-1′s importance in cellular signaling and membrane dynamics. p-caveolin-1 (B-9) monoclonal antibody enables researchers to gain valuable insights into the functional roles of caveolin-1 in health and disease, making this reagent an indispensable tool for studies in cell biology and signaling pathways.

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p-caveolin-1 Antibody (B-9) References:

1. Constitutive and growth factor-regulated phosphorylation of caveolin-1 occurs at the same site (Tyr-14) in vivo: identification of a c-Src/Cav-1/Grb7 signaling cassette.  |  Lee, H., et al. 2000. Mol Endocrinol. 14: 1750-75. PMID: 11075810
2. Caveolin, a protein component of caveolae membrane coats.  |  Rothberg, KG., et al. 1992. Cell. 68: 673-82. PMID: 1739974
3. Morphological changes of the 3T3-L1 fibroblast plasma membrane upon differentiation to the adipocyte form.  |  Fan, JY., et al. 1983. J Cell Sci. 61: 219-30. PMID: 6885939
4. Characterization of caveolin-rich membrane domains isolated from an endothelial-rich source: implications for human disease.  |  Lisanti, MP., et al. 1994. J Cell Biol. 126: 111-26. PMID: 7517942
5. VIP21/caveolin, glycosphingolipid clusters and the sorting of glycosylphosphatidylinositol-anchored proteins in epithelial cells.  |  Zurzolo, C., et al. 1994. EMBO J. 13: 42-53. PMID: 8306971
6. Identification, sequence, and expression of caveolin-2 defines a caveolin gene family.  |  Scherer, PE., et al. 1996. Proc Natl Acad Sci U S A. 93: 131-5. PMID: 8552590
7. Molecular cloning of caveolin-3, a novel member of the caveolin gene family expressed predominantly in muscle.  |  Tang, Z., et al. 1996. J Biol Chem. 271: 2255-61. PMID: 8567687
8. Phosphorylation of caveolin by src tyrosine kinases. The alpha-isoform of caveolin is selectively phosphorylated by v-Src in vivo.  |  Li, S., et al. 1996. J Biol Chem. 271: 3863-8. PMID: 8632005
9. Expression of caveolin-3 in skeletal, cardiac, and smooth muscle cells. Caveolin-3 is a component of the sarcolemma and co-fractionates with dystrophin and dystrophin-associated glycoproteins.  |  Song, KS., et al. 1996. J Biol Chem. 271: 15160-5. PMID: 8663016

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p-caveolin-1 Antibody (B-9) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-p-caveolin-1 Antibody (B-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p-caveolin-1 Antibody (B-9) Specifications

Alternate Product Name: caveolin-1

Product Clone Name: B-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: Tyr 14

Epitope Target: caveolin-1

Epitope Species: human

Product Reactivity/Detection: Tyr 14 phosphorylated caveolin-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for p-caveolin-1 Antibody (B-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred caveolin-1 antibody is caveolin-1 Antibody (7C8): sc-53564.