Dvl-3/Dishevelled 3/DVL3 Antibody (4D3): sc-8027

Dvl-3 Antibody (4D3) is a mouse monoclonal IgG1 kappa light chain antibody that detects Dvl-3 in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP). Anti-Dvl-3 antibody (4D3) is raised against amino acids 607-704 of Dvl-3 of mouse origin. Dvl-3 (4D3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. Dvl-3 plays a crucial role in the Wnt signaling pathway, which is essential for various cellular processes, including cell proliferation, differentiation, and embryonic development. Dvl-3 is primarily located in the cytoplasm and is involved in the transduction of signals from the frizzled receptors to downstream effectors, influencing cellular responses during development and tissue homeostasis. Anti-Dvl-3 antibody (4D3) enables researchers to investigate Wnt pathway mechanisms, particularly important since pathway dysregulation has been implicated in numerous diseases, including cancer and neurodegenerative disorders.

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Dvl-3/Dishevelled 3/DVL3 Antibody (4D3) References:

1. Isolation and characterization of a mouse homolog of the Drosophila segment polarity gene dishevelled.  |  Sussman, DJ., et al. 1994. Dev Biol. 166: 73-86. PMID: 7958461
2. Dishevelled is a component of the frizzled signaling pathway in Drosophila.  |  Krasnow, RE., et al. 1995. Development. 121: 4095-102. PMID: 8575310
3. Human homologue sequences to the Drosophila dishevelled segment-polarity gene are deleted in the DiGeorge syndrome.  |  Pizzuti, A., et al. 1996. Am J Hum Genet. 58: 722-9. PMID: 8644734
4. cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene.  |  Pizzuti, A., et al. 1996. Hum Mol Genet. 5: 953-8. PMID: 8817329
5. Isolation and characterization of mouse dishevelled-3.  |  Tsang, M., et al. 1996. Dev Dyn. 207: 253-62. PMID: 8922524
6. A frizzled homolog functions in a vertebrate Wnt signaling pathway.  |  Yang-Snyder, J., et al. 1996. Curr Biol. 6: 1302-6. PMID: 8939578
7. Human dishevelled genes constitute a DHR-containing multigene family.  |  Semënov, MV. and Snyder, M. 1997. Genomics. 42: 302-10. PMID: 9192851
8. Overexpression of the mouse dishevelled-1 protein inhibits GSK-3beta-mediated phosphorylation of tau in transfected mammalian cells.  |  Wagner, U., et al. 1997. FEBS Lett. 411: 369-72. PMID: 9271238

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Dvl-3/Dishevelled 3/DVL3 Antibody (4D3) has 103 citations in a variety of scientific publications.

Primary antibodies like Anti-Dvl-3/Dishevelled 3/DVL3 Antibody (4D3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Dvl-3/Dishevelled 3/DVL3 Antibody (4D3) Specifications

Alternate Product Name: Dvl-3

Product Clone Name: 4D3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 607-704

Epitope Target: Dvl-3

Epitope Species: mouse

Product Reactivity/Detection: Dvl-3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 103 citations in various scientific publications

Available Conjugates/Forms for Dvl-3/Dishevelled 3/DVL3 Antibody (4D3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin