DPRP1 Antibody (A-5): sc-376399

DPRP1 Antibody (A-5) is a mouse monoclonal IgM antibody that detects DPRP1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DPRP1 (A-5) antibody is available as the non-conjugated form. DPRP1 protein, also known as dipeptidyl-peptidase IV-related protein 1 or DPP8, is a member of the peptidase S9B family and is characterized by prolyl oligopeptidase activity, which is crucial for regulating various biological processes. DPRP1 protein is predominantly localized in the cytoplasm and is widely expressed across multiple tissues, including placenta, brain, prostate, testis, and muscle, highlighting potential roles in diverse physiological functions. DPRP1′s ability to cleave Xaa-Pro dipeptides from N-termini of proteins is significant, as this action can influence activity of various substrates, including those involved in immune responses and T-cell activation. Additionally, DPRP1 protein interacts with specific voltage-gated potassium channels, which may alter their expression and biophysical properties, further underscoring importance in cellular signaling pathways. Given involvement in critical processes and association with diseases such as type 2 diabetes, obesity, and cancer, DPRP1 serves as a valuable target for research and therapeutic applications.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

DPRP1 Antibody (A-5) References:

1. Cloning, expression and chromosomal localization of a novel human dipeptidyl peptidase (DPP) IV homolog, DPP8.  |  Abbott, CA., et al. 2000. Eur J Biochem. 267: 6140-50. PMID: 11012666
2. Identification and characterization of human DPP9, a novel homologue of dipeptidyl peptidase IV.  |  Olsen, C. and Wagtmann, N. 2002. Gene. 299: 185-93. PMID: 12459266
3. Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases.  |  Qi, SY., et al. 2003. Biochem J. 373: 179-89. PMID: 12662155
4. Prolyl peptidases related to dipeptidyl peptidase IV: potential of specific inhibitors in drug discovery.  |  Van der Veken, P., et al. 2007. Curr Top Med Chem. 7: 621-35. PMID: 17352682
5. Docking-based 3D-QSAR study for selectivity of DPP4, DPP8, and DPP9 inhibitors.  |  Kang, NS., et al. 2007. Bioorg Med Chem Lett. 17: 3716-21. PMID: 17462890
6. Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitors.  |  Cox, JM., et al. 2007. Bioorg Med Chem Lett. 17: 4579-83. PMID: 17562364
7. Irreversible inhibition of dipeptidyl peptidase 8 by dipeptide-derived diaryl phosphonates.  |  Van der Veken, P., et al. 2007. J Med Chem. 50: 5568-70. PMID: 17958345
8. Dipeptidyl peptidase-IV enzymatic activity bearing molecules in human brain tumors--good or evil?  |  Busek, P., et al. 2008. Front Biosci. 13: 2319-26. PMID: 17981714

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DPRP1 Antibody (A-5) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-DPRP1 Antibody (A-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DPRP1 Antibody (A-5) Specifications

Alternate Product Name: DPRP1

Product Clone Name: A-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 11-80

Epitope Target: DPRP1

Epitope Species: human

Product Reactivity/Detection: DPRP1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for DPRP1 Antibody (A-5): N/A