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GGT1 Antibody (3E6): sc-100746

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Datasheets
  • GGT1 Antibody (3E6) is a mouse monoclonal IgG2a κ, cited in 11 publications, provided at 100 µg/ml
  • raised against recombinant GGT1 of human origin
  • recommended for detection of GGT1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
  • At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for GGT1 Antibody (3E6). This work is in progress.

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GGT1 Antibody (3E6) is a mouse monoclonal IgG2a antibody that detects GGT1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). GGT1 plays a crucial role in the metabolism of glutathione, acting as a glutathionase that facilitates the transfer of the glutamyl moiety of glutathione to amino acids and dipeptides, which is essential for cellular detoxification processes and maintaining redox balance. GGT1 is predominantly located on the outer surface of the cell membrane, where GGT1 is involved in the absorption and secretion of various substances, highlighting its importance in liver function and overall metabolic health. Elevated levels of GGT1 in the bloodstream can serve as an early biomarker for liver damage and hepatocellular carcinoma, making GGT1 a significant target for clinical diagnostics. Notably, GGT1 exhibits marked heterogeneity in human serum and tissues, primarily due to variations in glycosylation rather than differences in gene expression, which underscores the complexity of its regulation and function in different physiological contexts. Anti-GGT1 antibody (3E6) is an invaluable tool for researchers investigating liver diseases and the biochemical pathways involving glutathione metabolism.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

GGT1 Antibody (3E6) References:

  1. Phenotypic characterization of Ggt1(dwg/dwg) mice,a mouse model for hereditary γ-glutamyltransferase deficiency.  |  Yamada, K., et al. 2013. Exp Anim. 62: 151-7. PMID: 23615310
  2. Pyrazole-based potent inhibitors of GGT1: Synthesis, biological evaluation, and molecular docking studies.  |  Mansha, M., et al. 2016. Eur J Med Chem. 124: 666-676. PMID: 27620969
  3. Apoplastic gamma-glutamyl transferase activity encoded by GGT1 and GGT2 is important for vegetative and generative development.  |  Giaretta, S., et al. 2017. Plant Physiol Biochem. 115: 44-56. PMID: 28319794
  4. Family-based analysis of GGT1 and HNF1A gene polymorphisms in patients with polycystic ovary syndrome.  |  Xu, X., et al. 2018. Reprod Biomed Online. 36: 115-119. PMID: 29169850
  5. Crystal structures of glutathione- and inhibitor-bound human GGT1: critical interactions within the cysteinylglycine binding site.  |  Terzyan, SS., et al. 2021. J Biol Chem. 296: 100066. PMID: 33187988
  6. N-Acetyl-l-cysteine restores reproductive defects caused by Ggt1 deletion in mice.  |  Wang, L., et al. 2021. Clin Transl Med. 11: e510. PMID: 34459136
  7. Genetic polymorphisms of GGT1 gene (rs8135987, rs5751901 and rs2017869) are associated with neoadjuvant chemotherapy efficacy and toxicities in breast cancer patients.  |  Sun, L., et al. 2023. BMC Med Genomics. 16: 267. PMID: 37891571
  8. GGT1 Suppresses the Development of Ferroptosis and Autophagy in Mouse Retinal Ganglion Cell Through Targeting GCLC.  |  Xu, G., et al. 2023. Eye Brain. 15: 139-151. PMID: 38020723
  9. The discovery of GGT1 as a novel gene for ischemic stroke conferring protection against disease risk in non-smokers and non-abusers of alcohol.  |  Solodilova, M., et al. 2024. J Stroke Cerebrovasc Dis. 33: 107685. PMID: 38522756
  10. GGT1 is a SNP eQTL gene involved in STAT3 activation and associated with the development of Post-ERCP pancreatitis.  |  Furukawa, R., et al. 2024. Sci Rep. 14: 12224. PMID: 38806529

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

GGT1 Antibody (3E6)

sc-100746
100 µg/ml
$333.00

Can sc-100746: GGT1 (3E6) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?

Asked by: jerojero
Thank you for your question. Yes, sc-100746: GGT1 (3E6) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here: https://www.scbt.com/scbt/resources/protocols/immunoperoxidase-staining
Answered by: Technical Support
Date published: 2017-03-24
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Rated 5 out of 5 by from Great!It was good for western blotting , a strong single band was experssed in human endothelial cells (D3 cell line).
Date published: 2017-12-08
Rated 5 out of 5 by from Recently published!This monoclonal GGT1 Antibody (3E6) has been recently published several times within the last year for IHC and IF applications. Beautiful results!
Date published: 2017-02-07
Rated 4 out of 5 by from Good immunoperoxidase membrane staining inGood immunoperoxidase membrane staining in formalin-fixed, paraffin-embedded human testis tissue. -SCBT QC
Date published: 2015-04-17
Rated 4 out of 5 by from Positive signal in WB in NIH/3T3 whole cell lysatePositive signal in WB in NIH/3T3 whole cell lysate. -SCBT QC
Date published: 2015-01-24
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GGT1 Antibody (3E6) is rated 4.5 out of 5 by 4.
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