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The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. This catalytic subunit is not present in the immunoproteasome and is replaced by catalytic subunit 3i (proteasome beta 8 subunit). Multiple transcript variants encoding different isoforms have been found for this gene.
Gene Name: | proteasome (prosome, macropain) subunit, beta type, 5 |
Family/Subfamily: | Protease , Threonine T1 |
Synonyms: | PSMB5, Proteasome chain 6, Proteasome subunit MB1, Proteasome subunit X, Proteasome catalytic subunit 3, Macropain epsilon chain, MB1, LMPX, Proteasome beta 5 subunit, Proteasome epsilon chain, Proteasome subunit beta type-5 |
Target Sequences: | NM_002797 NP_002788.1 P28074 |
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