HPS-6 Antibody (C-12): sc-373786

HPS-6 Antibody (C-12) is a mouse monoclonal IgG2a kappa light chain antibody that detects HPS-6 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). HPS-6 (C-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The Hermansky-Pudlak syndrome 6 protein (HPS-6), also known as Ruby-eye protein homolog (Ru), plays a crucial role in regulating lysosome function and synthesizing lysosomes and other specialized organelles. This regulation is vital for maintaining cellular homeostasis and ensuring proper cellular function, as lysosomes are responsible for degrading and recycling cellular waste, thus preventing toxic material accumulation. HPS-6 interacts with HPS-5 to form the biogenesis of lysosome-related organelles complex-2 (BLOC2), which is essential for the normal functioning of lysosome-related organelles. Defects in the HPS6 gene can lead to Hermansky-Pudlak syndrome 6, a condition characterized by oculocutaneous albinism, lysosomal storage defects, and prolonged bleeding due to platelet storage pool deficiency. With exceptional detection capabilities across various applications, anti-HPS-6 antibody (C-12) serves as an invaluable tool for researchers studying the molecular mechanisms underlying Hermansky-Pudlak syndrome and related lysosomal disorders.

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HPS-6 Antibody (C-12) References:

1. Phenotypic and molecular characteristics of hyperplastic polyposis.  |  Rashid, A., et al. 2000. Gastroenterology. 119: 323-32. PMID: 10930367
2. Ru2 and Ru encode mouse orthologs of the genes mutated in human Hermansky-Pudlak syndrome types 5 and 6.  |  Zhang, Q., et al. 2003. Nat Genet. 33: 145-53. PMID: 12548288
3. BRAF and KRAS mutations in colorectal hyperplastic polyps and serrated adenomas.  |  Chan, TL., et al. 2003. Cancer Res. 63: 4878-81. PMID: 12941809
4. The Hermansky-Pudlak syndrome 3 (cocoa) protein is a component of the biogenesis of lysosome-related organelles complex-2 (BLOC-2).  |  Gautam, R., et al. 2004. J Biol Chem. 279: 12935-42. PMID: 14718540
5. Characterization of BLOC-2, a complex containing the Hermansky-Pudlak syndrome proteins HPS3, HPS5 and HPS6.  |  Di Pietro, SM., et al. 2004. Traffic. 5: 276-83. PMID: 15030569
6. Normal lytic granule secretion by cytotoxic T lymphocytes deficient in BLOC-1, -2 and -3 and myosins Va, VIIa and XV.  |  Bossi, G., et al. 2005. Traffic. 6: 243-51. PMID: 15702992
7. A new genetic isolate with a unique phenotype of syndromic oculocutaneous albinism: clinical, molecular, and cellular characteristics.  |  Schreyer-Shafir, N., et al. 2006. Hum Mutat. 27: 1158. PMID: 17041891
8. Hemophagocytic syndrome after hematopoietic stem cell transplantation: a prospective observational study.  |  Abdelkefi, A., et al. 2009. Int J Hematol. 89: 368-373. PMID: 19252966
9. Parenchymal alterations in cirrhotic livers in patients with hepatopulmonary syndrome or portopulmonary hypertension.  |  Ma, C., et al. 2013. Liver Transpl. 19: 741-50. PMID: 23463612
10. Severe bleeding with subclinical oculocutaneous albinism in a patient with a novel HPS6 missense variant.  |  Han, CG., et al. 2018. Am J Med Genet A. 176: 2819-2823. PMID: 30369044
11. Hermansky-Pudlak syndrome: Five Chinese patients with novel variants in HPS1 and HPS6.  |  Wang, C., et al. 2021. Eur J Med Genet. 64: 104228. PMID: 33878481
12. Impairment of Renal Function in Hermansky-Pudlak Syndrome.  |  Yokoyama, T., et al. 2025. Am J Nephrol. 56: 25-34. PMID: 39383848

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HPS-6 Antibody (C-12) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-HPS-6 Antibody (C-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HPS-6 Antibody (C-12) Specifications

Alternate Product Name: HPS-6

Product Clone Name: C-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 400-446

Epitope Target: HPS-6

Epitope Species: human

Product Reactivity/Detection: Hermansky-Pudlak Syndrome Protein 6

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for HPS-6 Antibody (C-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin