MTHFD2 Antibody (243.1): sc-100750
- MTHFD2 Antibody (243.1) is a mouse monoclonal IgG2a κ, cited in 3 publications, provided at 100 µg/ml
- raised against recombinant MTHFD2 of human origin
- recommended for detection of MTHFD2 of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for MTHFD2 Antibody (243.1). This work is in progress.
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MTHFD2 Antibody (243.1) is a mouse monoclonal IgG2a antibody that detects MTHFD2 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). MTHFD2, also known as NMDMC, is a crucial bifunctional protein composed of 350 amino acids that plays a vital role in the interconversion of tetrahydrofolate derivatives, which are essential for the synthesis of purine, methionine, and thymidylate. MTHFD2 exhibits both methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities, requiring either NADP or NAD as cofactors for enzymatic functions. The activity of these cofactors is influenced by intracellular concentrations of magnesium and phosphate, highlighting the importance of cellular ion balance in metabolic processes. MTHFD2 operates as a homodimer and is predominantly localized in the mitochondria, where MTHFD2 is expressed during the development of normal tissue, underscoring its significance in cellular metabolism and energy production. Anti-MTHFD2 antibody (243.1) is an invaluable tool for researchers studying metabolic pathways and mitochondrial function in human cells.
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MTHFD2 Antibody (243.1) References:
- The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation. | Shang, M., et al. 2021. Nat Commun. 12: 1940. PMID: 33782411
- MTHFD2 facilitates breast cancer cell proliferation via the AKT signaling pathway. | Huang, J., et al. 2021. Exp Ther Med. 22: 703. PMID: 34007312
- MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function. | Sugiura, A., et al. 2022. Immunity. 55: 65-81.e9. PMID: 34767747
- Identification of MTHFD2 as a prognostic biomarker and ferroptosis regulator in triple-negative breast cancer. | Zhang, H., et al. 2023. Front Oncol. 13: 1098357. PMID: 36726381
- MTHFD2 reprograms macrophage polarization by inhibiting PTEN. | Shang, M., et al. 2023. Cell Rep. 42: 112481. PMID: 37149861
- MTHFD2 promotes PD-L1 expression via activation of the JAK/STAT signalling pathway in bladder cancer. | Li, L., et al. 2023. J Cell Mol Med. 27: 2922-2936. PMID: 37480214
- Targeting MTHFD2 to Exploit Cancer-Specific Metabolism and the DNA Damage Response. | Ramos, L., et al. 2024. Cancer Res. 84: 9-16. PMID: 37922465
- Induction of MTHFD2 in Macrophages Inhibits Reactive Oxygen Species-mediated NF-κB Activation and Protects against Inflammatory Responses. | Cui, Y., et al. 2024. J Immunol. 212: 1345-1356. PMID: 38407485
- MTHFD2-mediated redox homeostasis promotes gastric cancer progression under hypoxic conditions. | Mo, HY., et al. 2024. Redox Rep. 29: 2345455. PMID: 38723197
- Nuclear localization of MTHFD2 is required for correct mitosis progression. | Pardo-Lorente, N., et al. 2024. Nat Commun. 15: 9529. PMID: 39532843
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MTHFD2 Antibody (243.1) | sc-100750 | 100 µg/ml | $333.00 |