TICAM2 / TRAM

toll-like receptor adaptor molecule 2

Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response.Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes.

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Products

Antibodies (44)

Proteins (8)

Type

Over-Expression Lysate (2)

Primary (44)

Recombinant (6)

Target

TICAM2 / TRAM (52)

Reactivity

Human (36)

Mouse (16)

Rat (8)

Bovine (4)

Chicken (3)

Chimpanzee (3)

Dog (3)

Guinea pig (3)

Horse (3)

Monkey (5)

Opossum (1)

Orangutan (3)

Pig (3)

Rabbit (3)

Xenopus (3)

Zebrafish (3)

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Application

IHC (6)

IHC-P (3)

WB (41)

ELISA (11)

ICC (1)

IF (2)

Host

rabbit (43)

goat (1)

Isotype

IgG (16)

Clonality

polyclonal pc (44)

Format

APC (2)

APC Conjugated (3)

Azide-free (1)

Biotin Conjugated (5)

Cy3 Conjugated (2)

Cy7 Conjugated (2)

FITC Conjugated (5)

HRP Conjugated (5)

PE Conjugated (3)

Unconjugated (19)

Epitope

aa20-196 (8)

aa22-205 (8)

aa12-41 (7)

N-Terminus (4)

aa168-217 (4)

C-Terminus (2)

aa1-232 (1)

aa1-235 (1)

aa150-200 (1)

aa87-103 (1)

Publications

No (52)

Tag

GST (1)

GST, N-terminus (1)

His (1)

His-GST (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (6)

Mouse (1)

Source

293T Cells (1)

E. coli (4)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (3)

Select

TICAM2 / TRAM Antibody LS-C363

Antibody:

TICAM2 / TRAM Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

0.1 mg/$460

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TICAM2 / TRAM Antibody LS-C344

Antibody:

TICAM2 / TRAM Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IF, WB

Format:

Unconjugated

Price:

0.1 mg/$460

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TICAM2 / TRAM Antibody (aa87-103) LS-C148195

Antibody:

TICAM2 / TRAM Rabbit anti-Human Polyclonal (aa87-103) Antibody

Reactivity:

Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$386

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TICAM2 / TRAM Antibody (aa1-235) LS-C378004

Antibody:

TICAM2 / TRAM Rabbit anti-Human Polyclonal (aa1-235) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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TICAM2 / TRAM Antibody (aa150-200) LS-C148635

Antibody:

TICAM2 / TRAM Rabbit anti-Human Polyclonal (aa150-200) Antibody

Reactivity:

Mouse, Bovine, Rat, Opossum, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$386

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TICAM2 / TRAM Antibody (C-Terminus) LS-C10828

Antibody:

TICAM2 / TRAM Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µg/$649

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TICAM2 / TRAM Antibody LS-C405066

Antibody:

TICAM2 / TRAM Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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TICAM2 / TRAM Antibody (aa12-41) LS-C325727

Antibody:

TICAM2 / TRAM Rabbit anti-Human Polyclonal (aa12-41) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

TICAM2 / TRAM Antibody (aa12-41, Biotin) LS-C271479

Antibody:

TICAM2 / TRAM Rabbit anti-Human Polyclonal (aa12-41) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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TICAM2 / TRAM Antibody (aa12-41, FITC) LS-C271480

Antibody:

TICAM2 / TRAM Rabbit anti-Human Polyclonal (aa12-41) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

TICAM2 / TRAM Antibody (aa12-41, APC) LS-C271477

Antibody:

TICAM2 / TRAM Rabbit anti-Human Polyclonal (aa12-41) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

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TICAM2 / TRAM Antibody (aa12-41, Azide-free, HRP) LS-C271481

Antibody:

TICAM2 / TRAM Rabbit anti-Human Polyclonal (aa12-41) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

TICAM2 / TRAM Antibody (aa12-41, PE) LS-C271483

Antibody:

TICAM2 / TRAM Rabbit anti-Human Polyclonal (aa12-41) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

Select

TICAM2 / TRAM Antibody LS-C781490

Antibody:

TICAM2 / TRAM Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µl/$357

Select

TICAM2 / TRAM Antibody (aa20-196) LS-C374903

Antibody:

TICAM2 / TRAM Rabbit anti-Mouse Polyclonal (aa20-196) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261

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TICAM2 / TRAM Antibody (aa20-196, PE) LS-C727873

Antibody:

TICAM2 / TRAM Rabbit anti-Mouse Polyclonal (aa20-196) (PE) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521

• Unconjugated
• PE

• Unconjugated
• PE

Select

TICAM2 / TRAM Antibody (aa1-232) LS-C39775

Antibody:

TICAM2 / TRAM Goat anti-Mouse Polyclonal (aa1-232) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$941

Select

TICAM2 / TRAM Antibody (C-Terminus) LS-C10827

Antibody:

TICAM2 / TRAM Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$649

Select

TICAM2 / TRAM Antibody LS-C409828

Antibody:

TICAM2 / TRAM Rabbit anti-Human Polyclonal Antibody

Reactivity:

Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

Select

TICAM2 / TRAM Antibody (N-Terminus) LS-C345613

Antibody:

TICAM2 / TRAM Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

TICAM2 / TRAM Antibody (aa12-41) LS-C161872

Antibody:

TICAM2 / TRAM Rabbit anti-Human Polyclonal (aa12-41) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

Select

TICAM2 / TRAM Antibody (aa168-217) LS-C187381

Antibody:

TICAM2 / TRAM Rabbit anti-Human Polyclonal (aa168-217) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

TICAM2 / TRAM Antibody (aa22-205) LS-C296710

Antibody:

TICAM2 / TRAM Rabbit anti-Human Polyclonal (aa22-205) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225

Select

TICAM2 / TRAM Antibody LS-C783460

Antibody:

TICAM2 / TRAM Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

25 µg/$281; 100 µg/$400

Select

TICAM2 / TRAM Antibody LS-C661034

Antibody:

TICAM2 / TRAM Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Format:

Unconjugated

Price:

100 µg/$351

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