RNH1 Antibody (F-1): sc-166683
- RNH1 Antibody (F-1) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 200 µg/ml
- raised against a peptide mapping near the N-terminus of RNH1 of human origin
- recommended for detection of RNH1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for RNH1 Antibody (F-1) for WB and IHC(P) applications. These reagents are now offered in bundles with RNH1 Antibody (F-1) (see ordering information below).
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RNH1 Antibody (F-1) is a mouse monoclonal IgG2b antibody that detects RNH1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). RNH1, known as the placental ribonuclease inhibitor, is a crucial 460-amino acid protein characterized by a high content of leucine and cysteine residues, which contributes to structural stability and functional versatility. RNH1 plays a vital role in regulating mRNA turnover by binding to and inhibiting a wide range of intracellular and extracellular ribonucleases, effectively keeping them in a latent form. Notably, RNH1 also interacts with angiogenin, a member of the RNase A superfamily, thereby inhibiting angiogenesis—a process essential for tumor growth and metastasis. By modulating angiogenesis, RNH1 may have significant implications in cancer gene therapy, making RNH1 a valuable target for therapeutic interventions. Anti-RNH1 antibody (F-1) is an essential tool for researchers investigating the intricate roles of ribonuclease inhibitors in cellular processes and their potential impact on cancer biology.
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RNH1 Antibody (F-1) References:
- Interaction of human placental ribonuclease with placental ribonuclease inhibitor. | Shapiro, R. and Vallee, BL. 1991. Biochemistry. 30: 2246-55. PMID: 1998683
- Rnh1 promotes differentiation and myelination via RhoA in oligodendrocytes. | Zhao, CF., et al. 2013. Cell Tissue Res. 353: 381-9. PMID: 23624614
- Modular mutagenesis of human placental ribonuclease inhibitor, a protein with leucine-rich repeats. | Lee, FS. and Vallee, BL. 1990. Proc Natl Acad Sci U S A. 87: 1879-83. PMID: 2408043
- Knockout of the Ribonuclease Inhibitor Gene Leaves Human Cells Vulnerable to Secretory Ribonucleases. | Thomas, SP., et al. 2016. Biochemistry. 55: 6359-6362. PMID: 27806571
- Ribonuclease 1 attenuates septic cardiomyopathy and cardiac apoptosis in a murine model of polymicrobial sepsis. | Zechendorf, E., et al. 2020. JCI Insight. 5: PMID: 32213712
- The Role of Ribonuclease 1 and Ribonuclease Inhibitor 1 in Acute Kidney Injury after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair. | Zechendorf, E., et al. 2020. J Clin Med. 9: PMID: 33066382
- LRR-protein RNH1 dampens the inflammasome activation and is associated with COVID-19 severity. | Bombaci, G., et al. 2022. Life Sci Alliance. 5: PMID: 35256513
- Functional status analysis of RNH1 in bladder cancer for predicting immunotherapy response. | Chen, S., et al. 2023. Sci Rep. 13: 12625. PMID: 37537337
- AZGP1 deficiency promotes angiogenesis in prostate cancer. | Wen, RM., et al. 2024. J Transl Med. 22: 383. PMID: 38659028
- Ribonuclease inhibitor 1 emerges as a potential biomarker and modulates inflammation and iron homeostasis in sepsis. | Neu, C., et al. 2024. Sci Rep. 14: 14972. PMID: 38951571
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RNH1 Antibody (F-1) | sc-166683 | 200 µg/ml | $316.00 | |||
RNH1 Antibody (F-1): m-IgGκ BP-HRP Bundle | sc-534809 | 200 µg Ab; 40 µg BP | $354.00 | |||
RNH1 Antibody (F-1): m-IgG2b BP-HRP Bundle | sc-549302 | 200 µg Ab; 10 µg BP | $354.00 | |||
RNH1 (F-1) Neutralizing Peptide | sc-166683 P | 100 µg/0.5 ml | $68.00 |