SCCA1 Antibody (8H11): sc-21767
- SCCA1 Antibody (8H11) is a mouse monoclonal IgG1 κ SCCA1 antibody, cited in 13 publications, provided at 200 µg/ml
- raised against recombinant human SCCA1
- SCCA1 Antibody (8H11) is recommended for detection of SCCA1 of human origin by WB, IP, IF and IHC(P)
- SCCA1 Antibody (8H11) is available conjugated to agarose for IP; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for Gel Supershift and ChIP applications (sc-21767 X, 200 µg/0.1 ml)
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of SCCA1 (8H11): sc-21767.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for SCCA1 Antibody (8H11) for WB and IHC(P) applications. These reagents are now offered in bundles with SCCA1 Antibody (8H11) (see ordering information below).
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SCCA1 Antibody (8H11) is a mouse monoclonal IgG1 kappa light chain antibody that detects the SCCA1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. SCCA1 (8H11) antibody is available in both non-conjugated and various conjugated forms, including agarose, phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SCCA1, a member of the serpin family, plays a crucial role in regulating serine proteases, which are enzymes that can promote tumor metastasis by degrading extracellular matrix components. This regulation is vital because it helps maintain the balance between proteolytic activity and tissue integrity, thereby influencing cancer progression. The SCCA1 gene, located on human chromosome 18q21.3, is primarily expressed as SCCA1 and is associated with various cancer types, including cervical, lung, esophageal, and head and neck cancers, where SCCA1 levels increase with advancing disease stages. SCCA1 consists of 390 amino acids and was first identified in metastatic cervical squamous cell carcinoma, highlighting SCCA1′s significance as a biomarker for cancer diagnosis and prognosis. Anti-SCCA1 antibody (8H11) is an essential tool for researchers studying the mechanisms of cancer metastasis and the role of serpins in tumor biology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SCCA1 Antibody (8H11) References:
- Serum concentrations of squamous cell carcinoma antigen in patients with vulvar intraepithelial neoplasia and vulvar cancer. | Hefler, L., et al. 1999. Int J Cancer. 84: 299-303. PMID: 10371350
- Isolation and characterisation of adenoid squamous carcinoma cells highly producing SCC antigen and CEA from carcinoma of the maxillary sinus. | Kishimoto, H., et al. 2000. Oral Oncol. 36: 70-5. PMID: 10889923
- The impact of squamous cell carcinoma (SCC) antigen in the follow-up after radiotherapy in patients with cervical cancer. | Micke, O., et al. 2000. Anticancer Res. 20: 5113-5. PMID: 11326679
- SCCA1 expression in T-lymphocytes peripheral to cancer cells is associated with the elevation of serum SCC antigen in squamous cell carcinoma of the tongue. | Yasumatsu, R., et al. 2001. Cancer Lett. 167: 205-13. PMID: 11369142
- Novel forms of squamous cell carcinoma antigen transcripts produced by alternative splicing. | Suminami, Y., et al. 2001. Biochim Biophys Acta. 1519: 122-6. PMID: 11406281
- Radioimmunoassay for tumor antigen of human cervical squamous cell carcinoma. | Kato, H. and Torigoe, T. 1977. Cancer. 40: 1621-8. PMID: 332328
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SCCA1 Antibody (8H11) | sc-21767 | 200 µg/ml | $316.00 | |||
SCCA1 Antibody (8H11): m-IgG Fc BP-HRP Bundle | sc-526614 | 200 µg Ab; 10 µg BP | $354.00 | |||
SCCA1 Antibody (8H11): m-IgG1 BP-HRP Bundle | sc-531987 | 200 µg Ab; 20 µg BP | $354.00 | |||
SCCA1 Antibody (8H11) X | sc-21767 X | 200 µg/0.1 ml | $316.00 | |||
SCCA1 Antibody (8H11) AC | sc-21767 AC | 500 µg/ml, 25% agarose | $416.00 | |||
SCCA1 Antibody (8H11) FITC | sc-21767 FITC | 200 µg/ml | $330.00 | |||
SCCA1 Antibody (8H11) PE | sc-21767 PE | 200 µg/ml | $343.00 | |||
SCCA1 Antibody (8H11) Alexa Fluor® 488 | sc-21767 AF488 | 200 µg/ml | $357.00 | |||
SCCA1 Antibody (8H11) Alexa Fluor® 546 | sc-21767 AF546 | 200 µg/ml | $357.00 | |||
SCCA1 Antibody (8H11) Alexa Fluor® 594 | sc-21767 AF594 | 200 µg/ml | $357.00 | |||
SCCA1 Antibody (8H11) Alexa Fluor® 647 | sc-21767 AF647 | 200 µg/ml | $357.00 | |||
SCCA1 Antibody (8H11) Alexa Fluor® 680 | sc-21767 AF680 | 200 µg/ml | $357.00 | |||
SCCA1 Antibody (8H11) Alexa Fluor® 790 | sc-21767 AF790 | 200 µg/ml | $357.00 |