TFPI-2 Antibody (B-7): sc-48380
- TFPI-2 Antibody (B-7) is a mouse monoclonal IgG1 κ TFPI-2 antibody, cited in 8 publications, provided at 200 µg/ml
- raised against amino acids 71-190 of TFPI-2 of human origin
- TFPI-2 Antibody (B-7) is recommended for detection of TFPI-2 of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-TFPI-2 Antibody (B-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of TFPI-2 (B-7): sc-48380.
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for TFPI-2 Antibody (B-7) for WB and IHC(P) applications. This reagent is now offered in a bundle with TFPI-2 Antibody (B-7) (see ordering information below).
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TFPI-2 Antibody (B-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects TFPI-2 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-TFPI-2 antibody (B-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TFPI-2, also known as placental protein 5, plays a crucial role in blood coagulation regulation by inhibiting factor Xa activity and the factor VIIa-tissue factor complex, which is essential for the extrinsic coagulation pathway. This regulation is vital for maintaining hemostatic balance and preventing excessive clot formation, particularly in pathological conditions such as thrombosis. TFPI-2 is a multivalent, Kunitz-type proteinase inhibitor that circulates in association with plasma lipoproteins, including very low-density lipoprotein, low-density lipoprotein, and high-density lipoprotein, highlighting TFPI-2′s importance in lipid metabolism and cardiovascular health. TFPI-2′s ability to modulate coagulation pathways makes this protein a significant target for research in cardiovascular diseases and related disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TFPI-2 Antibody (B-7) References:
- The coagulation cascade: initiation, maintenance, and regulation. | Davie, EW., et al. 1991. Biochemistry. 30: 10363-70. PMID: 1931959
- Structure of the human lipoprotein-associated coagulation inhibitor gene. Intro/exon gene organization and localization of the gene to chromosome 2. | Girard, TJ., et al. 1991. J Biol Chem. 266: 5036-41. PMID: 2002045
- Characterization of the inhibition of tissue factor in serum. | Broze, GJ. and Miletich, JP. 1987. Blood. 69: 150-5. PMID: 3024756
- Studies of a mechanism inhibiting the initiation of the extrinsic pathway of coagulation. | Rao, LV. and Rapaport, SI. 1987. Blood. 69: 645-51. PMID: 3492226
- Evidence that a second human tissue factor pathway inhibitor (TFPI-2) and human placental protein 5 are equivalent. | Kisiel, W., et al. 1994. Blood. 84: 4384-5. PMID: 7994054
- Human tissue factor pathway inhibitor (TFPI) gene: complete genomic structure and localization on the genetic map of chromosome 2q. | Enjyoji, K., et al. 1993. Genomics. 17: 423-8. PMID: 8104873
- Assignment of the human PP5/TFPI-2 gene to 7q22 by FISH and PCR-based human/rodent cell hybrid mapping panel analysis. | Miyagi, Y., et al. 1996. Genomics. 35: 267-8. PMID: 8661135
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TFPI-2 Antibody (B-7) | sc-48380 | 200 µg/ml | $316.00 | |||
TFPI-2 Antibody (B-7): m-IgG Fc BP-HRP Bundle | sc-525560 | 200 µg Ab; 10 µg BP | $354.00 | |||
TFPI-2 Antibody (B-7) AC | sc-48380 AC | 500 µg/ml, 25% agarose | $416.00 | |||
TFPI-2 Antibody (B-7) HRP | sc-48380 HRP | 200 µg/ml | $316.00 | |||
TFPI-2 Antibody (B-7) FITC | sc-48380 FITC | 200 µg/ml | $330.00 | |||
TFPI-2 Antibody (B-7) PE | sc-48380 PE | 200 µg/ml | $343.00 | |||
TFPI-2 Antibody (B-7) Alexa Fluor® 488 | sc-48380 AF488 | 200 µg/ml | $357.00 | |||
TFPI-2 Antibody (B-7) Alexa Fluor® 546 | sc-48380 AF546 | 200 µg/ml | $357.00 | |||
TFPI-2 Antibody (B-7) Alexa Fluor® 594 | sc-48380 AF594 | 200 µg/ml | $357.00 | |||
TFPI-2 Antibody (B-7) Alexa Fluor® 647 | sc-48380 AF647 | 200 µg/ml | $357.00 | |||
TFPI-2 Antibody (B-7) Alexa Fluor® 680 | sc-48380 AF680 | 200 µg/ml | $357.00 | |||
TFPI-2 Antibody (B-7) Alexa Fluor® 790 | sc-48380 AF790 | 200 µg/ml | $357.00 |