Wnt-10a Antibody (C-9): sc-376029
- Wnt-10a Antibody (C-9) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 153-229 mapping within an internal region of Wnt-10a of human origin
- recommended for detection of Wnt-10a of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Wnt-10a Antibody (C-9) for WB applications. These reagents are now offered in bundles with Wnt-10a Antibody (C-9) (see ordering information below).
Wnt-10a Antibody (C-9) is a mouse monoclonal IgG1 antibody that detects Wnt-10a in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Wnt-10a, a 417 amino acid protein secreted into the extracellular matrix, plays a crucial role in cell signaling as a ligand for frizzled proteins, which are essential for various developmental processes, including the regulation of cell fate and embryogenesis. Anti-Wnt-10a antibody (C-9) has revealed significant involvement in the development of the central nervous system, where Wnt-10a acts as a signaling molecule that influences cellular communication and differentiation. Notably, overexpression of Wnt-10a has been linked to the pathogenesis of several carcinomas, indicating Wnt-10a′s significant role in tumor development and metastasis. Additionally, mutations in the gene encoding Wnt-10a are responsible for odonto-onycho-dermal dysplasia (OODD), a rare autosomal recessive disorder characterized by dry hair, onychodysplasia, and hyperkeratosis of the skin, further highlighting Wnt-10a′s critical biological functions. Wnt-10a monoclonal antibody (C-9) serves as an invaluable tool for researchers investigating the complex roles of Wnt signaling in health and disease.
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Wnt-10a Antibody (C-9) References:
- Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a β-catenin-dependent mechanism. | Cawthorn, WP., et al. 2012. Bone. 50: 477-89. PMID: 21872687
- Down-regulation of Wnt10a affects odontogenesis and proliferation in mesenchymal cells. | Liu, Y., et al. 2013. Biochem Biophys Res Commun. 434: 717-21. PMID: 23603361
- Clinical significance and biological role of Wnt10a in ovarian cancer. | Li, P., et al. 2017. Oncol Lett. 14: 6611-6617. PMID: 29163692
- The oncogenic role of Wnt10a in colorectal cancer through activation of canonical Wnt/β-catenin signaling. | Li, J., et al. 2019. Oncol Lett. 17: 3657-3664. PMID: 30881490
- Depletion of WNT10A Prevents Tumor Growth by Suppressing Microvessels and Collagen Expression. | Kumagai, M., et al. 2019. Int J Med Sci. 16: 416-423. PMID: 30911276
- WNT10A induces apoptosis of senescent synovial resident stem cells through Wnt/calcium pathway-mediated HDAC5 phosphorylation in OA joints. | Cao, X., et al. 2021. Bone. 150: 116006. PMID: 34000432
- Novel Dental Anomaly-associated Mutations in WNT10A Protein Binding Sites. | Kantaputra, P., et al. 2023. Int Dent J. 73: 79-86. PMID: 35537890
- Deletion of Wnt10a Is Implicated in Hippocampal Neurodegeneration in Mice. | Zhang, JH., et al. 2022. Biomedicines. 10: PMID: 35884806
- Prediction of the invasiveness of PTMC by a combination of ultrasound and the WNT10A gene. | Yan, Z., et al. 2022. Front Endocrinol (Lausanne). 13: 1026059. PMID: 36605938
- Phenotypic characteristics of taurodontism and a novel WNT10A variant in non-syndromic oligodontia family. | Zhao, Y., et al. 2023. Arch Oral Biol. 154: 105759. PMID: 37422997
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Wnt-10a Antibody (C-9) | sc-376029 | 200 µg/ml | $316.00 | |||
Wnt-10a Antibody (C-9): m-IgG Fc BP-HRP Bundle | sc-540498 | 200 µg Ab; 10 µg BP | $354.00 | |||
Wnt-10a Antibody (C-9): m-IgG1 BP-HRP Bundle | sc-542161 | 200 µg Ab; 20 µg BP | $354.00 |